Announcements

Editor’s Choice Articles are selected based on suggestions from the Academic Editors of Biomedicines (ISSN: 2227-9059). The Editors select a small number of published articles that they consider to be particularly interesting to our readers or important in their respective fields of research. You are therefore invited to read our Editor’s Choice Articles, a curated list of high-quality articles published in Biomedicines in 2025. The full list of Editor’s Choice Articles can be viewed via the following link:
https://www.mdpi.com/journal/biomedicines/editors_choice.

1. “Animal Models for Studying Developmental Origins of Cardiovascular–Kidney–Metabolic Syndrome”
by You-Lin Tain, Ying-Jui Lin and Chien-Ning Hsu
Biomedicines 2025, 13(2), 452; https://doi.org/10.3390/biomedicines13020452
Available online: https://www.mdpi.com/2227-9059/13/2/452
“An interesting and updated selection of experimental studies in an important subject stimulating further investigations.”

2. “Enhancing Cardiovascular Risk Prediction with a Simplified Carotid IMT Protocol: Evidence from the IMPROVE Study”
by Fabrizio Veglia, Anna Maria Malagoni, Mauro Amato, Rona J. Strawbridge, Kai Savonen, Philippe Giral, Antonio Gallo, Matteo Pirro, Bruna Gigante, Per Eriksson et al.
Biomedicines 2025, 13(3), 584; https://doi.org/10.3390/biomedicines13030584
Available online: https://www.mdpi.com/2227-9059/13/3/584
“This manuscript shows results derived from the IMPROVE study, describing how carotid intima-media thickness is able to significantly improve the predictive capacity of cardiovascular risk scores.”

3. “Synergistic Effects of Green Nanoparticles on Antitumor Drug Efficacy in Hepatocellular Cancer”
by Mirela Claudia Rîmbu, Liliana Popescu, Mirela Mihăilă, Roxana Colette Sandulovici, Daniel Cord, Carmen-Marinela Mihăilescu, Mona Luciana Gălățanu, Mariana Panțuroiu, Carmen-Elisabeta Manea, Adina Boldeiu et al.
Biomedicines 2025, 13(3), 641; https://doi.org/10.3390/biomedicines13030641
Available online: https://www.mdpi.com/2227-9059/13/3/641
“I recommend this article because it reveals the synergistic antitumor effects of plant-derived nanoparticles synthesized from Melissa officinalis and Clematis vitalba when combined with conventional hepatic anticancer drugs. The extraction of nanoparticles from natural sources represents a novel and promising research direction with considerable potential for clinical applications. Moreover, the study systematically evaluates the toxicity of various nanoparticles and drugs, offering extensive data that serve as a valuable reference in the fields of biology and pharmaceuticals.”

4. “Personalized Nutrition in Chronic Kidney Disease”
by Nishigandha Pradhan, Jennifer Kerner, Luciana A. Campos and Mirela Dobre
Biomedicines 2025, 13(3), 647; https://doi.org/10.3390/biomedicines13030647
Available online: https://www.mdpi.com/2227-9059/13/3/647
“Dietary requirements in healthy individuals vary with age. Older individuals with chronic kidney disease who reduce their protein intake have worse nutritional status and physical performance than those who do not decrease their protein intake. This article nicely summarizes the personalized nutrition in chronic kidney disease.”

5. “Severe Asthma and Active SARS-CoV-2 Infection: Insights into Biologics”
by Sara Manti, Michela Leotta, Federica D’Amico, Simone Foti Randazzese, Giuseppe Fabio Parisi and Salvatore Leonardi
Biomedicines 2025, 13(3), 674; https://doi.org/10.3390/biomedicines13030674
Available online: https://www.mdpi.com/2227-9059/13/3/674
“The authors address current issues very diligently and with the utmost accuracy and up-to-dateness. I particularly like the article on COVID-19, as it serves to keep attention focused on the pandemic that has affected millions of people in recent years.”

6. “Application of the Human Proteome in Disease, Diagnosis, and Translation into Precision Medicine: Current Status and Future Prospects”
by Yawen Xie, Xiaoying Chen, Maokai Xu and Xiaochun Zheng
Biomedicines 2025, 13(3), 681; https://doi.org/10.3390/biomedicines13030681
Available online: https://www.mdpi.com/2227-9059/13/3/681
“This review provides a comprehensive and forward-looking overview of the role of human proteomics in advancing our understanding of disease mechanisms, biomarker discovery, and precision medicine. By bridging technological developments with clinical applications, the authors effectively highlight current achievements while also discussing key challenges that remain, emphasizing the significant translational potential of proteome-based approaches.”

7. “Investigating the Prognostic Role of Telomerase-Related Cellular Senescence Gene Signatures in Breast Cancer Using Machine Learning”
by Qiong Li and Hongde Liu
Biomedicines 2025, 13(4), 826; https://doi.org/10.3390/biomedicines13040826
Available online: https://www.mdpi.com/2227-9059/13/4/826
“Machine Learning (a form of AI) was used to achieve prognostic evaluation of breast cancer patients. Nineteen genes were identified for the study, and changes in their levels of expression was confirmed by biochemical and cell biological methods. The study was described well, and the data were analyzed competently. Overall, this is a nice paper and should be read by researchers and clinicians.  The authors are known for performing studies on various human diseases using similar approaches.”

8. “The Role of NK Cells in Cancer Immunotherapy: Mechanisms, Evasion Strategies, and Therapeutic Advances”
by Paula Morcillo-Martín-Romo, Javier Valverde-Pozo, María Ortiz-Bueno, Maurizio Arnone, Laura Espinar-Barranco, Celia Espinar-Barranco and María Eugenia García-Rubiño
Biomedicines 2025, 13(4), 857; https://doi.org/10.3390/biomedicines13040857
Available online: https://www.mdpi.com/2227-9059/13/4/857
“This is a well-structured and informative review that addresses a topic of considerable current interest in cancer immunotherapy. Its clear synthesis of NK-cell mechanisms, immune-evasion pathways, and therapeutic advances gives the manuscript strong clinical and translational relevance, with likely broad appeal to the journal’s readership.”

9. “Comprehensive Integrated Analysis Reveals the Spatiotemporal Microevolution of Cancer Cells in Patients with Bone-Metastatic Prostate Cancer”
by Yinghua Feng, Xiuli Zhang, Guangpeng Wang, Feiya Yang, Ruifang Li, Lu Yin, Dong Chen, Wenkuan Wang, Mingshuai Wang, Zhiyuan Hu et al.
Biomedicines 2025, 13(4), 909; https://doi.org/10.3390/biomedicines13040909
Available online: https://www.mdpi.com/2227-9059/13/4/909
“This is a high-impact original research paper. It presents a large-scale single-cell analysis of bone-metastatic prostate cancer, described as the largest dataset of its kind in this disease context, encompassing 124 samples and more than 600,000 cells, and identifies evolutionary patterns, a novel epithelial subpopulation, and metastasis-associated metabolic features. The scale, methodological currency, and disease relevance make it not only a useful data resource but also a compelling Editor’s Choice candidate.”

10. “Kidney Transplantation in Congenital Abnormalities of Kidney and Urinary Tract (CAKUT)”
by Silvio Maringhini and Lars Pape
Biomedicines 2025, 13(4), 932; https://doi.org/10.3390/biomedicines13040932
Available online: https://www.mdpi.com/2227-9059/13/4/932
“A review of a neglected but relevant group of patients who undergo kidney transplant, in which new protocols are needed.”

11. “A Systematic Review of Pneumonitis Following Treatment with Immune Checkpoint Inhibitors and Radiotherapy”
by Melina Yerolatsite, Nanteznta Torounidou, Anna-Lea Amylidi, Iro-Chrisavgi Rapti, George Zarkavelis, Eleftherios Kampletsas and Paraskevi V. Voulgari
Biomedicines 2025, 13(4), 946; https://doi.org/10.3390/biomedicines13040946
Available online: https://www.mdpi.com/2227-9059/13/4/946
“As a review paper, it addresses a highly consequential and increasingly common clinical problem at the intersection of immunotherapy and radiotherapy. The manuscript synthesizes evidence from 58 studies comprising 4889 patients and emphasizes risk factors, management challenges, and the need for predictive biomarkers and models. This review has clear value for a wide clinical audience.”

12. “Druggability Studies of Benzene Sulfonamide Substituted Diarylamide (E3) as a Novel Diuretic”
by Hang Zhang, Shuyuan Wang, Nannan Li, Yue Xu, Zhizhen Huang, Yukun Zhang, Jing Li, Yinglin Zuo, Min Li, Runtao Li et al.
Biomedicines 2025, 13(4), 992; https://doi.org/10.3390/biomedicines13040992
Available online: https://www.mdpi.com/2227-9059/13/4/992
“This manuscript identifies E3, a novel and potent inhibitor of urea transporters (UTs) that produces diuretic effects without causing electrolyte imbalance, which addresses a key limitation of many existing diuretics. The study provides strong mechanistic evidence to demonstrate that the compound acts primarily through UT-A1 inhibition. In addition, the compound shows good pharmacokinetics, metabolic stability, and safety in animal models, and it effectively improves hyponatremia, suggesting its potential as a new class of diuretics with therapeutic value.”