Cellular Biology of Brain Angiogenesis

Dear Colleagues,

At the embryo stage, the development of brain vasculature includes three different phases: vasculogenesis, angiogenesis and arterial specialization. Specific molecular events selectively drive each phase. Several growth factors and neurotropic molecules secreted by endothelial, glial and nervous cells act in a paracrine manner, leading to the correct neurovascular development. However, vascular remodeling also continues during adulthood. The perturbation of pathways controlling brain vascular homeostasis results in aberrant vessel morphogenesis and congenital vascular malformation development. This Special Issue aims to collect research articles, reviews and communications focusing on mechanisms related to brain angiogenesis in both physiological and pathological conditions, as well as those related to oxidative damage. Moreover, submission of manuscripts describing the regulation of blood–brain barrier permeability and the cross-talk at the neurovascular unit is also encouraged. In this context, reports of single-cell transcriptomics, ATAC and methylome analysis can be considered for publication. Studies performed on human samples, cell lines and animal models can be considered.

Dr. Concetta Scimone
Dr. Rosalia D’Angelo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.