Special Issue "Inflammation-Associated Cancers: From Molecular Targets to Therapeutics"
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: 30 June 2020.
Inflammation is a physiological mechanism that, if unregulated, can became chronic, inducing malignant growth and tumorigenesis due to the persistent production of several inflammatory mediators. Oxidants, cytokines, chemokines, matrix metalloproteinases, and transcription factor populate the tumor microenvironment, acting directly on cancer cells, inhibiting their apoptosis, encouraging their proliferation, and leading to oncogenic mutations. Recently, therapeutic strategies to limit inflammatory cells and their mediators have been successful in pre-clinical and clinical tumor models. The Food and Drug Administration (FDA) approval of two recombinant cytokines, IL-2 and INF-α, for the treatment of numerous malignant diseases was the first demonstration that this kind of therapy could favor the balance between cancer and the anti-tumor immune response. These hopeful results open the route for new treatments able to reduce cancer-promoting inflammation and enhance anti-tumor efficacy.
In this Special Issue, contributions are encouraged to discuss pathogenesis and novel screening strategies, molecular targets, and therapeutics for inflammatory-associated cancer diseases. It is envisioned that this Special Issue will help readers to become more familiar with advances on discovery and development of effective treatments for inflammation-associated cancers.
Dr. Pasqualina Scognamiglio
Manuscript Submission Information
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