Special Issue "Eukaryotic Transcription Initiation and Elongation Mechanisms"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Genetics and Genomics".

Deadline for manuscript submissions: closed (31 May 2021).

Special Issue Editors

Dr. Heeyoun Bunch
E-Mail Website1 Website2
Guest Editor
Kyungpook National University, Agriculture & Life Science Building #1, Room 207, Daegu 41566, South Korea
Interests: transcriptional mechanisms; gene regulation; RNA polymerase II promoter-proximal pausing; ncRNA transcription; transcription-coupled DNA break and repair
Dr. Stuart K. Calderwood
E-Mail Website
Guest Editor
Beth Israel Deaconess Medical Center, Harvard Medical School, Department of Radiation Oncology, Boston, MA 02215, USA
Interests: oncology; heat shock proteins and HSF1; signal transduction; transcriptional regulation
Special Issues and Collections in MDPI journals
Dr. Benjamin P C Chen
E-Mail Website
Guest Editor
University of Texas Southwestern Medical Center, Department of Radiation Oncology, Dallas, Texas 75390, USA
Interests: DNA repair; cancer; DNA-PK

Special Issue Information

Dear Colleagues,

Transcription is one of the major DNA metabolisms and the first step of gene expression. It is a vigorous and dynamic process involving many transcription factors and nucleic acids to synthesize RNA molecules complementary to one of DNA double strands. In eukaryotic transcription, the enzyme activity and processivity of RNA polymerase II are regulated by a number of general and gene-specific transcriptional activators, repressors, and nucleosome modifiers. In recent years, RNA polymerase II promoter-proximal pausing in the early transcriptional elongation stage has been found to be an additional, major rate-limiting step along with the abortive initiation and promoter escape for productive transcription in metazoan cells. This issue aims to discuss the newly found transcription regulatory mechanisms during transcription initiation and elongation. In addition, genomic instability associated with transcriptional initiation and elongation in stimulus-inducible genes has been highlighted in recent studies. A DNA break that can introduce mutations to DNA and genes may be pathological and inherited and is thus overall an unwanted event. In addition to the R-loop instability and collision of replication–transcription machineries, instantaneous DNA break by topoisomerases is also required and spontaneously generated during transcription. Topoisomerases-mediated DNA break and genomic instability during transcription require collaboration and crosstalk between transcription and DNA repair factors, which is a relatively new research area, largely unknown. This issue discusses the mechanisms of DNA break and repair as well as the regulation of topoisomerases during transcription and gene expression.

Dr. Heeyoun Bunch
Dr. Stuart K. Calderwood
Dr. Benjamin P C Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Transcription initiation
  • Transcription elongation
  • RNA polymerase II
  • RNA polymerase II promoter-proximal pausing
  • Topoisomerase I
  • Topoisomerase II
  • Transcription-mediated genomic instability
  • Transcription-coupled DNA damage response signaling
  • Gene expression regulation

Published Papers

There is no accepted submissions to this special issue at this moment.
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