Translational Kidney Injury Models: From Rodents to Organoids, Precision-Cut Slices, and Microphysiologic Systems
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".
Deadline for manuscript submissions: 30 December 2026 | Viewed by 14
Special Issue Editor
Special Issue Information
Dear Colleagues,
Acute kidney injury (AKI) and chronic kidney disease (CKD) are driven by complex, multicellular processes that are not fully captured by traditional experimental models, and this mismatch has contributed to slow and often unsuccessful translation of preclinical discoveries into effective therapies. This Special Issue focuses on contemporary kidney injury models spanning in vivo, ex vivo, and in vitro platforms, with particular emphasis on their mechanistic fidelity, reproducibility, and alignment with human disease. We invite submissions on refined rodent models of AKI, CKD, and the AKI–CKD transition; precision cut kidney slices as ex vivo platforms for fibrosis, toxicity, and drug response studies; human kidney organoids and induced pluripotent stem cell–derived systems; and microphysiologic or “organ on chip” models that integrate flow, immune components, and multi organ interactions. Studies that address model standardization, reporting guidelines, and cross-model comparison are especially encouraged. Submissions spanning basic mechanistic studies, model-guided biomarker discovery, and preclinical therapeutic testing are all welcome in this Special Issue. By assembling work across these complementary platforms, this Special Issue aims to clarify where each model is most informative, define best practices, and accelerate the development of truly predictive translational kidney injury models.
Prof. Dr. Babu J. Padanilam
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- acute kidney injury
- chronic kidney disease
- AKI–CKD transition
- animal models
- precision-cut kidney slices
- kidney organoids
- microphysiologic systems/organ on chip
- renal fibrosis
- nephrotoxicity
- translational nephrology
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
