AGAP2 and AGAP2-AS1: Roles and Regulation
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 663
Special Issue Editor
Interests: de-regulated signalling pathways; gene expression in cancer; AGAP2; selection of transcription start sites
Special Issue Information
Dear Colleagues,
The intricancy of the mechanisms available for gene regulation makes this a phenomenal area of study. These mechanisms become even more relevant when cell differentiation or cancer development and progression are considered. Once the layer of epigenetic regulation is added to our understanding of transcription factors, co-repressor and co-activator complexes and chromatin architecture, we are still left navigating the universe of non-coding RNA functions. Transcriptomic technologies have powered gene expression studies and led to the discovery of many types of regulatory RNAs. One of those regulatory RNAs are antisense long non-coding RNAs.
This Special Issue is dedicated to furthering our understanding of a sense/antisense gene pair whose expression has been linked to cancer: AGAP2 and AGAP2-AS1. AGAP2 overexpression has been associated with several cancers including glioblastoma, prostate and breast cancer, and to fibrosis and cellular processes ranging from lipid metabolism to migration and cell proliferation. On the other hand, the expression of AGAP2-AS1 is gaining relevance in gastric, breast and lung cancer, hepatocellular carcinoma and glioblastoma, proving to be a good biomarker for some of these malignancies.
For this Special Issue, we encourage the submission of manuscripts encompassing all aspects of the regulation and role of AGAP2 and AGAP2-AS1. We accept reviews and short- and full-size research papers.
Dr. Cristina Montiel-Duarte
Guest Editor
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Keywords
- AGAP2
- AGAP2-AS1
- antisense lncRNA
- gene regulation
- transcription regulation
- AKT
- proliferation
- migration
- survival
- cancer
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