Bone Mechanics: From Cells to Organs, to Function

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 775

Special Issue Editor


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Guest Editor
Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, Chile
Interests: functional morphology; musculoskeletal biology; biomechanics; musculoskeletal pathology

Special Issue Information

Dear Colleagues,

We invite you to contribute original articles to the Special Issue “Bone Mechanics: From Cells to Organs, to Function”, with a focus on advancing our understanding of bone physiology and function. As bone serves both mechanical and metabolic roles, studying its response to loads at a cell, tissue and organ level is essential for deciphering research questions across fields such as skeletal adaptation during evolution of species, consequences of ageing in humans, acute and chronic pathologies, among others.

We welcome submissions in basic research exploring bone mechanics in humans and animal models, including comparative studies that shed light on evolutionary patterns or translational relevance. Contributions may address topics such as mechanotransduction, structural analysis, age-related changes, and innovative experimental or computational methods to assess bone response to loads.

This Special Issue aims to bridge disciplines, from biomechanics and histology to evolutionary biology and biomedical engineering, highlighting the importance of research questions, classic and new methods and results, and methodological rigor in the study of skeletal systems.

Join us in deepening the dialogue on how bones grow, adapt, weaken, and fail across the lifespan and among diverse organisms.

Dr. Viviana Toro-Ibacache
Guest Editor

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Keywords

  • bone mechanics
  • bone remodeling
  • mechanotransduction
  • structural analysis
  • functional morphology
  • bioengineering

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Published Papers (1 paper)

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Research

23 pages, 13904 KB  
Article
Total Flavonoids of Rhizoma drynariae Enhance Bone Marrow Mesenchymal Stem Cell-Mediated Tendon–Bone Healing by Promoting Tissue Regeneration, Angiogenesis, and Modulation of Cytokine Expression
by Gaoyuan Yang, Yu Wang, Xianyan Xie, Ziyan Li, Shuqi Qin, Weitong Zhang, Zixi Chenyuan, Peizhong Cao, Huiguo Wang and Lin Zhu
Biology 2025, 14(11), 1593; https://doi.org/10.3390/biology14111593 - 14 Nov 2025
Viewed by 517
Abstract
(1) Objective: This study aimed to investigate the synergistic effect and underlying mechanisms of Total Flavonoids of Rhizoma drynariae (TFRD) in combination with Bone Marrow Mesenchymal Stem Cells (BMSCs) in the repair of tendon–bone injuries. (2) Methods: The effects of TFRD on the [...] Read more.
(1) Objective: This study aimed to investigate the synergistic effect and underlying mechanisms of Total Flavonoids of Rhizoma drynariae (TFRD) in combination with Bone Marrow Mesenchymal Stem Cells (BMSCs) in the repair of tendon–bone injuries. (2) Methods: The effects of TFRD on the proliferation and migration of BMSCs were assessed using CCK-8 and scratch assays, and its potential to promote osteogenic and chondrogenic differentiation was evaluated. Concurrently, the pro-angiogenic effect of TFRD on Human Umbilical Vein Endothelial Cells (HUVECs) was observed. In vivo, a rat model of Achilles tendon–bone injury was established and animals were divided into four groups: SHAM, Model, BMSCs, and BMSCs + TFRD. After an 8-week intervention, the level of functional recovery was evaluated through histological analysis, immunohistochemistry, serum biochemical analysis, and biomechanical testing. (3) Results: A concentration of 5.0 μg/mL TFRD significantly promoted the proliferation, migration, and differentiation of BMSCs and enhanced the tube formation capacity of HUVECs. In the BMSCs + TFRD group, histological analysis revealed well-organized collagen fibers, increased cartilage deposition, and an optimized tendon–bone interface (TBI) structure. Immunohistochemistry showed upregulated expression of COL I, COL II, and SOX-9, alongside downregulated VEGFA. Furthermore, serum IL-6 levels were decreased, while IL-10 and TGF-β levels were elevated. The biomechanical properties were also significantly improved in this group. (4) Conclusions: TFRD promotes tendon–bone healing and functional recovery by enhancing BMSC functions, promoting angiogenesis, and improving the local microenvironment. Full article
(This article belongs to the Special Issue Bone Mechanics: From Cells to Organs, to Function)
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