Regulatory Mechanisms of Gene Expression and Its Regulatory Networks

Dear Colleagues,

Gene expression is a strictly regulated process, from prenatal development to aging. Understanding the intricate mechanisms governing gene expression—including transcriptional, post-transcriptional, translational, and epigenetic regulation—is crucial for unraveling the complexity of cellular biological systems. Recent advances in genomics, transcriptomics, and computational biology have shed light on the dynamic orchestration of cell-specific gene expression, revealing their pivotal roles in determining cellular processes, development, and evolution. Dysregulation of these mechanisms is implicated in various pathologies, including cancer, neurodegenerative disorders, congenital anomalies, and metabolic diseases, making this field of study both fundamental and translational. Increasingly, the context of gene expression regulation is being explored in therapeutic scenarios, since many drugs influence gene expression regulatory processes. These epidrugs may act in several epigenetic mechanisms, including DNA methylation, histone modifications, and chromatin remodeling.

We are pleased to invite you to contribute to this Special Issue by exploring novel insights into transcriptional regulation, non-coding RNAs, epigenetic mechanisms, signaling pathways, gene ontologies, and systems biology approaches to decipher regulatory mechanisms of gene expression.

This Special Issue aims to highlight the advances in our understanding of how gene expression is controlled and how these mechanisms can be harnessed for therapeutic and biotechnological applications.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

I. Transcriptional and epigenetic regulation of gene expression;
II. Single-cell transcriptomics and multi-omics approaches applied to gene regulation studies;
III. DNA methylation, histone modifications, and chromatin assessment methodologies;
IV. Roles of non-coding RNAs in gene expression control;
V. Post-transcriptional and translational regulatory mechanisms;
VI. Systems biology and graph theory to study gene regulatory networks;
VII. Dysregulation of gene expression in disease and therapeutic targeting;
VIII. Epidrugs’, epi-teratogens’, and epi-vitamins’ roles in gene regulation;
IX. Study of gene regulation mechanisms through an evolutionary perspective;
X. Advances in technologies for studying gene regulation.

We look forward to receiving your contributions.

Dr. Thayne Woycinck Kowalski
Dr. Giovanna Câmara Giudicelli
Dr. Ionara Rodrigues Siqueira
Guest Editors

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• transcriptional regulation
• gene regulatory networks
• epigenetic mechanisms
• non-coding RNAs
• functional genomics
• multi-omics integration
• signaling pathways
• systems biology
• epidrugs
• pharmaco-transcriptomics