Breaking Barriers in Metabolic Health: Novel Insights into Obesity and Metabolic Disorders

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 480

Special Issue Editor


E-Mail Website1 Website2
Guest Editor
1. School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
2. Zhongshan Institute for Drug Discovery, Chinese Academy of Sciences, Guangzhou 528400, China
Interests: metabolism diseases; lipid overload; insulin resistance; pathogenic molecules; biomarkers; drug therapy
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Special Issue Information

Dear Colleagues,

Obesity, a complex chronic inflammatory condition characterized by adipose tissue dysfunction and expansion, plays a central role in driving metabolic syndrome, diabetes, liver disease, and cardiovascular complications, collectively constituting one of the most pressing global health challenges. To effectively combat these disorders, it is essential to deepen our understanding of the metabolic pathways underlying disease progression, along with contributing factors such as lifestyle, environmental, genetic, and epigenetic factors. Innovative pharmacological strategies targeting critical processes such as energy homeostasis, chronic inflammation, insulin resistance, and organ-specific metabolic dysfunction offer promising therapeutic potential. Conducting rigorous research in these domains is vital for uncovering core molecular mechanisms and converting these insights into effective, evidence-based strategies to improve the prevention and management of metabolic disorders globally. This Special Issue, "Breaking Barriers in Metabolic Health: Novel Insights into Obesity and Metabolic Disorders", seeks to compile high-impact research that advances our understanding of disease mechanisms and identifies actionable biomarkers. We encourage submissions of original research articles, reviews and short communications addressing, but not limited to, the following themes:

  1. Molecular and cellular mechanisms driving metabolic disorders;
  2. Identification and characterization of novel biomarkers in metabolic disorders;
  3. Genetic, epigenetic, and environmental contributions to metabolic disorders.

Dr. Aijun Qiao
Guest Editor

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Keywords

  • metabolic disorders
  • pathogenesis and mechanisms
  • biomarkers

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Published Papers (1 paper)

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Research

22 pages, 4333 KB  
Article
Uncovering Potential Neutrophil-Related Biomarkers for Early AMI Diagnosis
by Yuwei Liu, Yun Zhang, Lucheng Wang, Diru Yao, Ebenezeri Erasto Ngowi, Moussa Omorou, Ning Hou, Weibo Dai, Longlong Wang, Guihua Yue and Aijun Qiao
Biology 2026, 15(10), 781; https://doi.org/10.3390/biology15100781 (registering DOI) - 14 May 2026
Viewed by 114
Abstract
Early diagnosis of AMI is crucial for improving patient outcomes, yet current clinical tools often lack the requisite sensitivity and specificity for reliable early detection. As neutrophils are the first innate immune responders mobilized following infarction, we employed an integrated multi-omics and machine [...] Read more.
Early diagnosis of AMI is crucial for improving patient outcomes, yet current clinical tools often lack the requisite sensitivity and specificity for reliable early detection. As neutrophils are the first innate immune responders mobilized following infarction, we employed an integrated multi-omics and machine learning approach to identify neutrophil-driven molecular signatures with diagnostic potential. By analyzing multiple peripheral blood transcriptomic datasets, we conducted differential expression and immune infiltration analyses, followed by machine learning-based feature selection to pinpoint key genes linked to neutrophil activity. Integration of these findings with single-cell transcriptomic data further clarified the neutrophil-specific expression patterns of candidate genes during AMI progression. Using a joint diagnostic model, we identified MCEMP1, NFE2, and AQP9 as the most informative predictors, with MCEMP1 emerging as the primary contributor. Experimental validation in a murine model of myocardial infarction (MI) confirmed rapid upregulation of MCEMP1 after injury, closely mirroring the kinetics of neutrophil infiltration. Collectively, these findings delineate a neutrophil-associated molecular profile of early AMI and highlight MCEMP1 as a promising noninvasive biomarker and a potential therapeutic target for modulating neutrophil-driven myocardial injury. Full article
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