Epilepsy: The Mechanisms of Seizure, Termination, and Biomarker Development

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 345

Special Issue Editor


E-Mail Website
Guest Editor
Department of Clinical Physiology, School of Medical Sciences, Fujita Health University, Toyoake, Japan
Interests: epilepsy

Special Issue Information

Dear Colleagues,

Epilepsy is a chronic neurological disorder characterized by recurrent seizures arising from abnormal neuronal activity. This Special Issue centers on the biological mechanisms underlying seizure initiation, propagation, and termination, shedding light on molecular, cellular, and network-level processes that contribute to epileptogenesis.

In addition to exploring the biological basis of treatment strategies—such as the effects of pharmacological agents on neural excitability and potential genetic targets—this issue emphasizes the development of biomarkers for epilepsy. These biological indicators promise to improve diagnostic accuracy, facilitate monitoring of disease progression, and guide personalized therapeutic approaches.

By highlighting cutting-edge research in seizure dynamics, treatment mechanisms, and biomarker innovation, this issue seeks to advance the fundamental understanding of epilepsy and inspire cross-disciplinary contributions from molecular neuroscience, systems biology, and therapeutic development.

We are currently accepting submissions of papers related to this Special Topic. We welcome contributions from diverse fields—including basic neuroscience, therapeutic strategies, and biomarker research.

Dr. Keisuke Maeda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epilepsy
  • epileptogenesis
  • seizure mechanisms
  • seizure dynamics
  • termination
  • biomarkers
  • neural excitability
  • neuroscience

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

22 pages, 2083 KB  
Review
State-Dependent Modulation of Neurotransmitter Systems in Epilepsy: A Mechanistic Framework for Seizure Dynamics and Biomarker Variability
by Ekaterina Andreevna Narodova
Biology 2026, 15(11), 850; https://doi.org/10.3390/biology15110850 (registering DOI) - 29 May 2026
Abstract
Epilepsy is increasingly conceptualized as a disorder of dynamic network instability rather than a static imbalance between excitation and inhibition. However, substantial variability in seizure occurrence, clinical expression, and treatment response remains insufficiently explained by existing models. This narrative review examines how neurotransmitter [...] Read more.
Epilepsy is increasingly conceptualized as a disorder of dynamic network instability rather than a static imbalance between excitation and inhibition. However, substantial variability in seizure occurrence, clinical expression, and treatment response remains insufficiently explained by existing models. This narrative review examines how neurotransmitter systems contribute to seizure dynamics within a state-dependent framework, in which factors such as sleep–wake cycles, stress, inflammation, and metabolic conditions modulate network excitability. The review identified four key findings: neurotransmitter function in epilepsy is state-dependent rather than fixed; multiple physiological state modifiers shape seizure susceptibility; seizure termination is an active state-sensitive process; and biomarker performance depends on the prevailing brain state. Evidence from experimental and clinical studies indicates that neurotransmitter function is context-sensitive and interacts with molecular pathways, including ion channel function, synaptic plasticity, and neuromodulatory signaling. These interactions influence key stages of seizure dynamics, including initiation, propagation, and termination, and may differ across etiological categories of epilepsy. This perspective also helps explain the limited performance of static biomarkers, as they do not capture temporal variability in network states. Instead, state-sensitive markers and context-aware interpretations of electrophysiological and clinical data may provide more informative insights. Overall, integrating neurotransmitter mechanisms with dynamic brain states offers a more precise perspective on seizure variability and may support the development of individualized, state-aware approaches to epilepsy management. Full article
Show Figures

Figure 1

Back to TopTop