Regeneration and Repair in the Central Nervous System

Dear Colleagues, 

Due to the limited intrinsic healing capacity of the adult CNS, neurotrauma in the form of traumatic brain injury (TBI), spinal cord injury (SCI), and stroke often results in permanent loss of motor, sensory, and/or cognitive function with devastating effects on an individual’s quality of life and a huge socioeconomic cost. In addition to the initial injury, neurotrauma also elicits a complex secondary injury pathophysiology including ischemia, excitotoxicity, and inflammation that lead to further neuronal and glial cell death, demyelination, and cystic cavity formation, creating multiple barriers to functional recovery. Furthermore, the capacity of spared and surviving axons for plasticity and growth is severely limited by growth inhibitors in CNS myelin and chondroitin sulfate proteoglycans (CSPGs) in the glial scar, as well as age-related and injury-induced deficiencies in intrinsic neuronal biochemistry. Although many of our colleagues have demonstrated that CNS axons can regenerate when provided with the appropriate environment or biochemical stimulation, there is no therapeutic intervention for neurotrauma that can effectively promote CNS regeneration and repair.

This Special Issue is open to original research articles, reviews, and communications that describe strategies for improving therapeutic interventions including drug delivery, gene therapy, exosome and cell therapy, nanotechnology, and tissue engineering approaches aimed at regeneration and repair after traumatic CNS trauma.

Dr. Jeoung Soo Lee
Prof. Dr. Megan Ryan Detloff
Guest Editors

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