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Bioengineering
Special Issues
Engineering Cells for Immunotherapy
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Engineering Cells for Immunotherapy

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1547

Special Issue Editor

Dr. Yun Chang

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Hong Kong Polytechnic University, Hong Kong, China
Interests: immunotherapy; cell engineering; bio-nanotechnology engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, "Engineering Cells for Immunotherapy", aims to spotlight recent advances in cell engineering strategies that enhance the effectiveness of immunotherapy against cancers and other diseases. This collection will include research on genetically modifying immune cells, such as CAR T cells, to improve their targeting and destruction of tumor cells, as well as techniques to enhance their persistence and functionality in the human body. Additionally, it will explore the integration of biomaterials, delivery systems, and synthetic biology tools that optimize the therapeutic potential and precision of engineered immune cells. By addressing both preclinical and clinical developments, the Special Issue will provide a comprehensive view of how engineering cells at the molecular and cellular levels can lead to innovative therapies with greater efficacy and fewer side effects. This initiative invites multidisciplinary contributions that intersect molecular biology, bioengineering, materials science, and clinical applications to provide a holistic approach to cell-based immunotherapies.

Dr. Yun Chang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell engineering
  • CAR T cells
  • immunotherapy
  • genetically modified immune cells
  • tumor targeting
  • synthetic biology
  • biomaterials for cell therapy
  • gene editing for immunotherapy
  • delivery systems
  • molecular immunoengineering
  • preclinical and clinical immunotherapies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

10 pages, 1177 KiB  
Article
Impact of Sex on Infection Risk in Patients with Systemic Lupus Erythematosus
by R. Borrelli, S. Nicola, F. Corradi, I. Badiu, L. Lo Sardo, N. Rashidy, A. Quinternetto, M. Mazzola, F. Meli, E. Saracco, I. Vitali, S. Negrini and L. Brussino
Bioengineering 2025, 12(1), 59; https://doi.org/10.3390/bioengineering12010059 - 13 Jan 2025
Viewed by 1392
Abstract
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that exhibits considerable diversity in terms of both clinical and immunological manifestations. Since its female-to-male ratio is around 9:1, it is well recognized that systemic lupus erythematosus mostly affects women, especially those of [...] Read more.
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that exhibits considerable diversity in terms of both clinical and immunological manifestations. Since its female-to-male ratio is around 9:1, it is well recognized that systemic lupus erythematosus mostly affects women, especially those of childbearing age. There is a greater susceptibility to infections in adult patients with systemic lupus erythematosus (SLE) compared to the general population. However, only a small number of studies have attempted to analyze this risk using real-life data, and even fewer have successfully assessed the influence of sex. Materials and Methods: A retrospective study was conducted, enrolling patients and dividing them into two groups based on their biological sex. Infectious episodes were identified from medical records and categorized by severity. Patients were stratified according to disease duration and treatment received. Logistic regression analysis was used to calculate the odds ratio (OR), with a 95% confidence interval (CI) for the assessment of risk factors. Multivariable logistic regression was performed to adjust for potential confounders. Model fit was evaluated using the Hosmer–Lemeshow test, and interactions between variables were tested. Sensitivity analyses were conducted to assess the robustness of the findings. Results: A total of 119 patients (107 females and 12 males) were included in the analysis. No significant difference in age was found between sexes (t = −0.715, p = 0.487), but disease duration was significantly shorter in males (t = 3.35, p = 0.003). Logistic regression showed a significant association between male sex and infection risk (β = 0.9426, p = 0.05), with males having an almost sixfold higher probability of infection compared to females (OR 5.675, 95% CI: 1.4479–22.2477, p = 0.0127). Disease duration (β = 0.0250, p = 0.102) and smoking status (β = 0.4529, p = 0.078) were not statistically significant. Lastly, correlation analysis revealed a significant association between SS-A antibodies and infection rate (r = 0.291, p = 0.003). Conclusions: This study highlights a significant sex-based disparity in the risk of infections among SLE patients, with males being at a higher risk compared to females. The differences in the distribution of infections, such as the higher prevalence of pneumonia in males and urinary tract infections in females, suggest that sex-specific factors, including immunological and hormonal differences, may influence infection susceptibility. Our findings emphasize the need for tailored clinical management, with increased vigilance for infections in male patients, to improve prevention strategies and targeted therapeutic interventions in this subgroup. Full article
(This article belongs to the Special Issue Engineering Cells for Immunotherapy)
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