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Bioengineering
Special Issues
Biological Tissue Regeneration Using Medical Materials
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Biological Tissue Regeneration Using Medical Materials

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 3706

Special Issue Editors

Prof. Dr. Osamu Yamamoto

E-Mail Website
Guest Editor
Graduate School of Science and Engineering, Yamagata University, Yonezawa 992-8510, Japan
Interests: grafting & therapeutic materials; tissue regeneration (skin, nerve, cartilage/bone, blood vessel, dura mater, and tendon); reconstructive surgery
Prof. Dr. Osamu Suzuki

E-Mail Website
Guest Editor
Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan
Interests: ceramics; calcium phosphate materials; scaffold; bone regeneration
Dr. Norio Fukuda

E-Mail Website
Guest Editor
Clinical division of Plastic and Reconstructive Surgery, Yamagata University Hospital, Yamagata 990-9585, Japan
Interests: wound healing; burn healing; bone reconstruction; scar contracture; plastic and reconstructive surgery; hand surgery

Special Issue Information

Dear Colleagues,

Biological tissue regeneration using medical materials such as collagen, gel, ceramics, polymers, and metals is drawing attention. Medical materials are appropriately designed to be minimally invasive and endogenously non-toxic, and their application is expected to promote tissue regeneration. In vitro evaluation using medical materials is important for tissue regeneration. Furthermore, in vivo evaluation using animal models is essential to ensure the safety of medical materials for living organisms before clinical trials. Such in vivo research on tissue regeneration using medical materials covers a wide range of fields, including skin, bone/cartilage, nerve, fascia/dura mater, etc. The research boundary between medicine and engineering will provide novel useful treatments for various diseases in the future. Original articles on new medical materials, in vivo/in vitro evaluation methods for regenerated tissues, and new knowledge to the advance medical care are welcome for this Special Issue. The specific topics of interest are as follows:

  • In vivo evaluation of the effects of medical materials in animal models and clinical trials, including tissue regeneration (bone, skin, nerve, cartilage, blood vessel, tendon, etc.) and medical materials (ceramics, polymers, metals, collagen, gel, etc.).
  • The interaction of medical materials with cells such as stem cells, fibroblasts, osteoblasts, etc.
  • In vitro evaluation of differentiation and proliferation on the surfaces of medical materials.
  • The functional evaluation of organs and vital tissues organized on/at the surface of medical materials.

Prof. Dr. Osamu Yamamoto
Prof. Dr. Osamu Suzuki
Dr. Norio Fukuda
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ceramics
  • polymers
  • metals
  • gel
  • collagen
  • in vivo/in vitro evaluation
  • cells
  • animal model
  • clinical trial
  • biological tissue regeneration

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Published Papers (3 papers)

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Research

24 pages, 8885 KiB  
Article
Fluorine-Incorporated Biogenic Hydroxyapatite Enhances Socket Bone Healing via Addressing Macrophage-Mediated Inflammatory Response
by Chengwu Liu, Leyao Xu, Junming Feng, Bo Yang, Kaidi Chen, Yuanxiang Liu, Xiayi Wu, Shiyu Wu, Zhipeng Li, Shoucheng Chen and Zhuofan Chen
Bioengineering 2025, 12(4), 396; https://doi.org/10.3390/bioengineering12040396 - 7 Apr 2025
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Abstract
Biological hydroxyapatite (BHA) has been extensively employed in alveolar socket preservation, yet its clinical application is often compromised by delayed bone healing triggered by macrophage-mediated pro-inflammatory responses. Building upon our previous work, in which we successfully incorporated fluorine into BHA to develop fluorinated [...] Read more.
Biological hydroxyapatite (BHA) has been extensively employed in alveolar socket preservation, yet its clinical application is often compromised by delayed bone healing triggered by macrophage-mediated pro-inflammatory responses. Building upon our previous work, in which we successfully incorporated fluorine into BHA to develop fluorinated biogenic hydroxyapatite (FBHA) with superior physicochemical and biological properties, this study systematically investigated the effects of fluorine doping on macrophage-mediated osteoimmunomodulation and socket bone healing. The synthesized FBHA was characterized using SEM, EDS, and fluoride ion release assays to confirm fluorine incorporation. In macrophage co-culture models, FBHA demonstrated significant advantages over BHA, effectively suppressing iNOS and TNFα gene expression, reducing NO release, and inhibiting phagocytic activity in M1 macrophages. RNAseq analysis revealed that the M1 phenotype suppression might be mediated through enhanced cellular antioxidant activity. Moreover, in macrophage-conditioned microenvironments, FBHA significantly upregulated osteogenic gene expression and ALP activity of pre-osteoblasts. In vivo experiments demonstrated FBHA’s superior performance in alveolar ridge preservation, especially in new bone formation and mineralization inside sockets. Fluorine doping significantly boosted socket bone healing via suppressing the inflammatory response of macrophages and enhancing osteogenic differentiation of pre-osteoblasts. These findings provide valuable insights into the development of next-generation biomaterials for alveolar socket preservation. Full article
(This article belongs to the Special Issue Biological Tissue Regeneration Using Medical Materials)
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12 pages, 3383 KiB  
Article
Comparison of Phacoemulsification and Aspiration Parameters in Cataract Surgery: Metal Tip vs. Hybrid Tip
by Kazuo Ichikawa, Kei Ichikawa, Seiji Tokiwa, Yuki Sato, Tomoyuki Miyazaki, Yoshiki Tanaka and Naoki Yamamoto
Bioengineering 2024, 11(12), 1195; https://doi.org/10.3390/bioengineering11121195 - 26 Nov 2024
Viewed by 1151
Abstract
Various tips are available for phacoemulsification in cataract surgery. Evidence-based data can inform ophthalmologists, especially inexperienced ones, on tip selection. We retrospectively evaluated the energy efficiency and other parameters of two ultrasonic phacoemulsification and aspiration tips across different nuclear hardness grades in 342 [...] Read more.
Various tips are available for phacoemulsification in cataract surgery. Evidence-based data can inform ophthalmologists, especially inexperienced ones, on tip selection. We retrospectively evaluated the energy efficiency and other parameters of two ultrasonic phacoemulsification and aspiration tips across different nuclear hardness grades in 342 cataract patients (342 eyes) with nuclear hardness grades II to IV. Surgical procedures, ultrasound settings, and instrumentation were standardized. All surgeries were performed by one experienced doctor. We compared the metal INTREPID® Balanced Tip (M-tip) with the INTREPID® Hybrid Tip (P-tip), which has a polymer coating. The M-tip required significantly less total ultrasound time and cumulative dissipated energy (CDE) than the P-tip for grades III and IV, while the P-tip had a shorter aspiration time and less estimated fluid aspirated for grade II. No differences in corneal endothelial cell loss were observed. Lens rupture rates were low: 0.47% for the M-tip and 0.78% for the P-tip. Multiple regression analysis showed that CDE increased with nuclear hardness. These findings suggest that the M-tip is efficient for harder lenses, while the P-tip may be advantageous for softer lenses, informing optimal tip selection in cataract surgery. Further research is suggested to elucidate their clinical significance. Full article
(This article belongs to the Special Issue Biological Tissue Regeneration Using Medical Materials)
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17 pages, 11990 KiB  
Article
Nerve Regeneration and Gait Function Recovery with Implantation of Glucose/Mannose Conduits Using a Rat Model: Efficacy of Glucose/Mannose as a New Neurological Guidance Material
by Osamu Yamamoto, Risa Saito, Yuta Ohseki and Asami Hoshino
Bioengineering 2024, 11(2), 157; https://doi.org/10.3390/bioengineering11020157 - 4 Feb 2024
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Abstract
Therapy with clinical nerve guidance conduits often causes functional incompleteness in patients. With the aim of better therapeutic efficacy, nerve regeneration and gait function were investigated in this study using a novel nerve guidance conduit consisting of glucose/mannose. The glucose/mannose nerve guidance conduits [...] Read more.
Therapy with clinical nerve guidance conduits often causes functional incompleteness in patients. With the aim of better therapeutic efficacy, nerve regeneration and gait function were investigated in this study using a novel nerve guidance conduit consisting of glucose/mannose. The glucose/mannose nerve guidance conduits were prepared by filling the conduits with the glucose/mannose aqueous solutions for different kinematic viscosity, which were applied to sciatic nerve defects (6 mm gap) in a rat model. The nerve regeneration effect and the gait function recovery with the fabricated nerve guidance conduits were examined. From the results of the XRD measurement, the glucose/mannose conduits were identified as crystal structures of cellulose type II. Young’s modulus and the maximum tensile strength of the crystalline glucose/mannose conduits demonstrated good strength and softness for the human nerve. Above 4 weeks postoperative, macroscopic observation revealed that the nerve was regenerated in the defective area. In various staining results of the nerve tissue removed at 4 weeks postoperative, myelinated nerves contributing to gait function could not be observed in the proximal and distal sites to the central nerve. At 8–12 weeks postoperative, myelinated nerves were found at the proximal and distal sites in hematoxylin/eosin staining. Glia cells were confirmed by phosphotungstic acid–hematoxylin staining. Continuous nerve fibers were observed clearly in the sections of the regenerated nerves towards the longitudinal direction at 12 weeks postoperative. The angle between the metatarsophalangeal joint and the ground plane was approximately 93° in intact rats. At 4 weeks postoperative, walking was not possible, but at 8 weeks postoperative, the rats were able to walk, with an angle of 53°. At 12 weeks postoperative, the angle increased further, reaching 65°, confirming that the rats were able to walk more quickly than at 8 weeks postoperative. These results demonstrated that gait function in rats treated with glucose/mannose nerve guidance conduits was rapidly recovered after 8 weeks postoperative. The glucose/mannose nerve guidance conduit could be applied as a new promising candidate material for peripheral nerve regeneration. Full article
(This article belongs to the Special Issue Biological Tissue Regeneration Using Medical Materials)
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