Oral Wound Healing and Material Engineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1221

Special Issue Editor


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Guest Editor
Department of Otolaryngology, Old Dominion University, Norfolk, VA 23529, USA
Interests: craniofacial surgery and regeneration; immunoregeneration; bone; oral; soft tissue; reconstruction

Special Issue Information

Dear Colleagues,

Oral wound healing occurs in the setting of high microbial burden, constant physical trauma, and the presence of saliva and is therefore different to cutaneous wound healing. Even though there are more than 13 million oral surgeries performed every year in the United States, there are currently limited therapeutics to address oral wound healing. Healing in the oral cavity is genetically different than cutaneous wound healing and is poorly understood, making it a promising area for therapy and bioengineering. The correlation between systemic health and oral health is well known, underscoring the importance of developing new therapies that address oral injury and healing. This Special Issue will focus on the novel biomaterials required to provide bioregenerative therapies to the mucosa and underlying bone. The oral cavity provides a complex environment where salivary fistulas can form from the mouth to the neck or mouth to the nose, making speech and eating problematic.

Prof. Dr. Steven L. Goudy
Guest Editor

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Keywords

  • oral
  • healing
  • regeneration
  • mucosa
  • bone
  • biomaterial

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Published Papers (1 paper)

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Review

31 pages, 2004 KB  
Review
Harnessing the Therapeutic Potential of Extracellular Vesicles for Oral Wound Healing
by Helly A. Patel, Bianca Schmiliver, Keerthi Priya Chinniyampalayam Sekar, Mirelle Dogini, Chidubem Onyeagoro, Daniel C. Shah, M. Hope Robinson, Babatunde Giwa-Otusajo, David T. Wu and Steven L. Goudy
Bioengineering 2026, 13(2), 148; https://doi.org/10.3390/bioengineering13020148 - 27 Jan 2026
Viewed by 928
Abstract
Oral wound healing is a robust process; however, complications from surgery, systemic diseases, and aging can impair healing. While some treatments exist, regenerative therapies to promote mucosal wound healing remain limited. In recent years, there has been a significant rise in FDA-approved cell-based [...] Read more.
Oral wound healing is a robust process; however, complications from surgery, systemic diseases, and aging can impair healing. While some treatments exist, regenerative therapies to promote mucosal wound healing remain limited. In recent years, there has been a significant rise in FDA-approved cell-based therapies; however, extracellular vesicles represent an emerging cell-free alternative that may mitigate risks associated with cellular therapies, including tumorigenesis and immunogenicity. These lipid-encapsulated nanovesicles can deliver therapeutic cargo, such as proteins, lipids, nucleic acids, or drugs, to the wound site. Extracellular vesicles can be derived from mesenchymal stromal cells, immune cells, bodily fluids, or bacteria, and engineered through genetic modification, preconditioning, or direct cargo loading to enhance therapeutic potency. Furthermore, advanced delivery platforms, including hydrogels, microneedles, and aerosols, allow for sustained and localized EV delivery to the oral wound site. This review examines differences between cutaneous and oral wound healing; factors that impair oral repair; extracellular vesicle sources and engineering strategies; and delivery strategies for developing EV-based therapeutics for oral wound healing. Full article
(This article belongs to the Special Issue Oral Wound Healing and Material Engineering)
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