Advancements in Tissue-Engineered Muscle
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 1323
Special Issue Editor
Interests: skeletal muscle mechanics; musculoskeletal tissue biomechanics; in vivo muscle behavior; soft tissue mechanics; neuromuscular diseases; orthopedic biomechanics; human movement; rehabilitation
Special Issue Information
Dear Colleagues,
Muscle tissue, a specialized, activatable material crucial for facilitating a broad range of voluntary movements from delicate facial expressions to vigorous activities like running, poses a unique challenge in tissue engineering. Derived from myoblasts, multinucleated muscle cells form well-organized fibers within a three-dimensional extracellular matrix (ECM), shaping skeletal muscle to meet diverse functional needs. Hence, engineering muscle tissues and mimicking their structural, functional, and mechanical properties present significant challenges.
Given these complexities, muscle tissue engineering holds promise in revolutionizing various fields, including regenerative medicine, bioengineering, and biomedical research. The ability to engineer functional muscle tissues opens avenues for disease modeling, drug screening, and tissue repair. This Special Issue aims to showcase the latest research breakthroughs and innovative approaches in this field.
We invite contributions that address various aspects, including but not limited to (i) scaffold design, (ii) cell sources and differentiation protocols, (iii) biophysical and biochemical cues such as mechanical loading, substrate stiffness, and biochemical signaling that guide muscle tissue development and regeneration, (iv) functional characterization and methodological advancements for assessing contractility and metabolic activity, and (v) clinical applications and translational studies in regenerative medicine applications, tissue repair, disease modeling, and biohybrid robotic systems. Contributions from diverse backgrounds, including bioengineering, biotechnology, tissue engineering, regenerative medicine, and biomedical sciences are requested in the form of original research articles, reviews, and perspectives on this Special Issue.
By bringing together cutting-edge research, we aim to foster interdisciplinary approaches and accelerate progress in muscle tissue engineering.
Dr. Filiz Ates
Guest Editor
Manuscript Submission Information
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Keywords
- skeletal muscle
- tissue engineering
- biomaterial scaffolds
- contractile force
- myoblasts
- satellite cells
- stem cells
- volumetric muscle loss
- muscle regeneration
- myogenic differentiation
- vascularization
- organ-on-chip
- nanofibers
- 3D printing
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