Special Issue "Towards a Systems Biology Approach"
Deadline for manuscript submissions: 31 May 2021.
Interests: clinical pharmacology, systems pharmacology, pharmacokinetics, biopharmaceutics, modeling and simulations
Interests: pharmacokinetics; pharmacokinetic-pharmacodynamic (PKPD) modeling; physiologically-based pharmacokinetic (PBPK) modeling; quantitative system pharmacology (QSP) modeling; in vivo-in vitro correlation (IVIVC) modeling; drug metabolism/pharmacokinetic screening; pharmaceutical analysis (LC-MS/MS, HPLC)
Advancement in experimental instrumentation and techniques coupled with enhanced computational powers has brought about the evolution of systems biology. This integrates quantifiable data with respective mechanisms to allow the understanding of the broader pathways and systems in the fields of biology, physiology, pharmacology and toxicology. However, it is acknowledged that there still remains much to be revealed in any system and that quantification is not always done for all the observations. Data availability and integrity are vital for the systems biology approach to be successful, and we need to uncover and quantify many more mechanisms and pathways in order to avoid models with excessive uncertainty and unnecessary assumptions.
Therefore, in this Special Issue, we would like to invite manuscripts describing not only successful cases of systems biology approach but also the data that contribute to efforts that enable such an approach. The specific scope of this Special Issue includes but is not limited to:
- Systems biology approach (encompassing the fields of biology, physiology, pharmacology and toxicology)
- In vitro, ex vivo and/or in vivo research that contributes to a future systems biology approach
- Novel experimental approach that uncovers novel data needed for a systems biology approach
- Novel method for the quantification of observations or improvement in quantitative methods that can be utilized in a systems biology approach
- Conventional modeling approach including physiology-relevant or physiologically based models that can lead to a systems biology approach
- Model simulations data based on appropriate assumptions and compelling hypotheses
Dr. Jong Bong Lee
Dr. Pavel Gershkovich
Dr. Tae Hwan Kim
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- systems biology
- systems pharmacology
- quantitative sciences
- modeling and simulations
- physiologically based model
- mathematical model