Special Issue "Smart Nano-Biointerfaces for Theranostics"

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: 29 February 2020.

Special Issue Editor

Prof. Dr. Cristina Satriano
E-Mail Website
Guest Editor
Department of Chemical Sciences, University of Catania, viale Andrea Doria, 6 95125 Catania, Italy
Interests: nanomaterials; biomaterials; drug delivery; stimuli-responsive materials; theranostics; surface tailoring; peptidomimetics; plasmonics; graphene oxide; hybrid biointerfaces; supported lipid bilayers; tissue repair; wound healing; cancer therapy; nanomedicine for neurodegenerative diseases.

Special Issue Information

Dear Colleagues,

Following the great interest gathered by the previous SI on “Nano-Biointerfaces for Biosensing”, we are launching another Special Issue collection of papers on the broadened topic of “Smart Nano-Biointerfaces for Theranostics”.

Theranostics is a novel concept which involves the incorporation of diagnosis (imaging) and therapy in a single nanoplatform, with an extraordinary potential for personalized medicine development. Indeed, the combination of various biomarkers, image contrast agents, therapeutic agents, and specific targeting ligands can provide optimized treatment for individuals and in the early detection of various diseases. Theranostics agents rely on multifaceted nanomaterials, which requires multidisciplinary and cross-disciplinary research efforts from chemistry, physics, material sciences, nanoscience and nanotechnology, biology, pharmacology, and medicine. An enhanced efficiency and spatiotemporal control for site-specific drug release, e.g., through the use of stimuli-responsive smart materials, the improved crossing of physiological barriers, and the promotion of response with minimum side effects are the different impacts experienced by the various in vitro and in vivo evaluations of theranostic platforms.

The topics to be focused on in this SI include the different synthetic approaches (e.g., by wet chemistry, plasma methods, and laser ablation) to get surface-tailored delivery systems (such as lipid nanoparticles, polymeric nanoparticles, inorganic nanoparticles, hydrogels) incorporating both imaging and therapeutic components, their testing for effective delivery to the target site (e.g., the tumor tissue or the central nervous system), as well as future perspectives for clinical applications. Contributions are expected to offer breakthrough research reports and new insights into the fabrication and physicochemical/biophysical/biological characterization of multifunctional nanoplatforms to be used at the interface with systems of biological interest for theranostic-oriented applications in several pathologies, including, but not limited to, cancer and neurodegenerative diseases.

Prof. Dr. Cristina Satriano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Nanomaterials
  • Surface functionalization
  • Biomolecule immobilization
  • Nanotechnology
  • Drug delivery
  • Imaging
  • Biosensing
  • Nanomedicine

Published Papers (1 paper)

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Open AccessArticle
Quantification of the PEGylated Gold Nanoparticles Protein Corona. Influence on Nanoparticle Size and Surface Chemistry
Appl. Sci. 2019, 9(22), 4789; https://doi.org/10.3390/app9224789 - 09 Nov 2019
The interactions of nanoparticles with living organisms are driven by an interface called the protein corona. This interface is formed when nanoparticles are introduced in biological milieu and proteins are adsorbed at nanoparticles’ surfaces. Understanding the factors that are responsible for the formation [...] Read more.
The interactions of nanoparticles with living organisms are driven by an interface called the protein corona. This interface is formed when nanoparticles are introduced in biological milieu and proteins are adsorbed at nanoparticles’ surfaces. Understanding the factors that are responsible for the formation and the composition of the protein corona could reveal mechanistic insights that are involved in the interaction of nanoparticles with biological structures. Multiple studies have qualitatively described the protein corona, but just a few have proposed quantification methods, especially for gold nanoparticles. Using bovine serum albumin conjugated with fluorescein-5-isothiocyanate as a model protein, we developed a fluorescent-based quantification method for gold nanoparticles’ protein coronas. The impact of nanoparticle size and surface chemistry was studied, and our research emphasizes that size and surface chemistry are determinant factors: Bigger nanoparticles and amino-modified surface chemistry are responsible for higher protein adsorption compared to smaller ones and carboxyl- or methoxy-modified surface chemistry. The proposed method can be used to complete the full picture of the interactions of nanoparticles with biological milieu and to describe the parameters which govern these interactions for the better development of nanomedicines. Full article
(This article belongs to the Special Issue Smart Nano-Biointerfaces for Theranostics)
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