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Synthesis and Biological Evaluation of New Compounds

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 288

Editors


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Guest Editor
Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria
Interests: polyphenolic compounds and biological activity; metal–polyphenol hybrid systems; antioxidant and antimicrobial compounds; supramolecular interactions in bioactive systems; organometallic and coordination compounds; computational chemistry of metal complexes; natural compounds and metal coordination; redox-active metal complexes; functional bioactive materials; pharmaceutical inorganic chemistry
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Microbiology, University of Food Technologies, 26 Maritza Blvd., 4002 Plovdiv, Bulgaria
Interests: antimicrobials; food microbiology; PCR diagnostics; immobilized cells; probiotics; microbial transformations
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Our society requires new innovations to drive progress and address specific challenges. In this regard, chemistry can contribute to this process through the discovery of new compounds with biological activity. These new compounds can be chemically synthesized or extracted and purified from natural sources and may hold great potential for use in the treatment of cancer, diabetes, cardiovascular diseases, and other pathologies; in pest control in agriculture and veterinary medicine; or in the disinfection of equipment, spaces, or surfaces, among other applications. In this Special Issue, we invite studies that describe the initial synthesis, isolation, preparation, characterization, and biological activities of chemical compounds that could have future applications in biology, medicine, pharmacy, medicinal chemistry, dental medicine, veterinary science, agriculture, and public health.

This Special Issue encourages a focus on the following topics:

  1. Synthesis: Methods and processes used to create compounds in a laboratory setting, including the development of novel synthesis techniques or improvements in existing ones.
  2. Biological Evaluation: The assessment of how these compounds interact with biological systems, including their potential therapeutic effects, toxicity, or applications in healthcare, such as in drug development, diagnostics, or treatment of diseases.

This title refers to research exploring the creation of new compounds, their uses in various applications, and their impacts or effectiveness in biological contexts.

Dr. Petja Marinova
Dr. Denica Blazheva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inorganic chemistry
  • organic chemistry
  • chemical compounds
  • synthesis
  • metal complexes
  • biological activity
  • medicinal chemistry
  • active compounds
  • biological applications
  • pharmaceutical biotechnology
  • drug discovery and development
  • pharmacology
  • anticancer research
  • cytotoxicity
  • apoptosis
  • antibacterial assays

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Published Papers (1 paper)

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Research

14 pages, 745 KB  
Communication
The Antibacterial Potential of Zn(II)–Cannabinoid Acid Equilibrium Systems Against Gram-Positive and Gram-Negative Microorganisms
by Magdalena Woźniczka, Weronika Gonciarz, Manas Sutradhar, Adília Januário Charmier, Susana Santos and Marek Pająk
Appl. Sci. 2026, 16(14), 7031; https://doi.org/10.3390/app16147031 (registering DOI) - 13 Jul 2026
Abstract
Interest is growing in the antimicrobial potential of the non-psychoactive cannabinoids, such as cannabidiolic acid (CBDA) and cannabigerolic acid (CBGA), and their metal systems. The present study follows on from previous potentiometric and ESI-MS studies confirming the formation of stable zinc(II) species with [...] Read more.
Interest is growing in the antimicrobial potential of the non-psychoactive cannabinoids, such as cannabidiolic acid (CBDA) and cannabigerolic acid (CBGA), and their metal systems. The present study follows on from previous potentiometric and ESI-MS studies confirming the formation of stable zinc(II) species with cannabinoid acids in an alcohol–water environment under physiological conditions. The antibacterial action of the compounds was assessed against reference Gram-negative strains (Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis) and Gram-positive strains (Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis) using minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) assays. Their cytotoxicity was also evaluated in vitro using mouse fibroblasts. The tested compounds were found to demonstrate pronounced selectivity against Gram-positive bacterial strains compared to Gram-negative bacteria. The antibacterial efficacy of the free ligands was enhanced by the presence of Zn(II) in the solution: the equilibrium mixtures exhibited greater inhibitory activity against E. faecalis and S. epidermidis, with MIC and MBC values being non-cytotoxic toward L929 fibroblasts under the tested in vitro conditions. However, Gram-negative bacteria were only found to be susceptible at elevated concentrations, which also induced cytotoxic effects. Among the free ligands, CBGA exhibited slightly stronger antibacterial activity than CBDA. Full article
(This article belongs to the Special Issue Synthesis and Biological Evaluation of New Compounds)
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