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Application of Nutrition and Clinical Exercise Physiology

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (20 March 2026) | Viewed by 802

Special Issue Editors


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Guest Editor
Department of Bromatology, Poznan University of Medical Sciences, 60-806 Poznan, Poland
Interests: diet; food science; food analysis; nutrition and disease; nutrition and health

E-Mail Website
Guest Editor
Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, 31-066 Kraków, Poland
Interests: diet; nutrition and health; lifestyle interventions

Special Issue Information

Dear Colleagues,

The contemporary approach to the prevention and treatment of lifestyle diseases is increasingly based on interdisciplinary strategies that include both a well-balanced diet and individually tailored physical activity. Clinical exercise physiology combined with nutrition science allows for a better understanding of the impact of these factors on the functioning of the body—both in healthy conditions and in the course of chronic diseases.

Topics include the use of dietary interventions and physical activity programmes in the treatment and prevention of metabolic, cardiovascular, respiratory, and autoimmune disorders. Equally important is the study of the mechanisms underlying these interventions, as well as their impact on quality of life, physical performance, body composition, and biochemical and hormonal parameters.

This Special Issue focuses on the practical and scientific aspects of the use of nutrition and exercise physiology in clinical practice and public health, encouraging the sharing of research results, literature reviews, and innovative therapeutic approaches.

Dr. Izabela Bolesławska
Dr. Pawel Jagielski
Guest Editors

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Keywords

  • clinical exercise physiology
  • nutrition and health
  • lifestyle interventions
  • chronic disease prevention
  • physical activity in clinical practice
  • metabolic health

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Published Papers (1 paper)

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14 pages, 988 KB  
Brief Report
DHA-Rich n-3 PUFA Supplementation Improves Morning Stiffness and Quality of Life in Patients with Rheumatoid Arthritis and Downregulates TNF-α Expression in PBMCs
by Alejandro A. Candia, Victoria Torres-Galaz, Camila Latapiatt, Denisse Valladares-Ide and Sebastián Jannas-Vela
Appl. Sci. 2026, 16(4), 1980; https://doi.org/10.3390/app16041980 - 17 Feb 2026
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Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease associated with joint pain, stiffness, functional impairment, and reduced quality of life. Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have been proposed as adjunctive therapies for RA due to their anti-inflammatory and pro-resolving properties; however, [...] Read more.
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease associated with joint pain, stiffness, functional impairment, and reduced quality of life. Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have been proposed as adjunctive therapies for RA due to their anti-inflammatory and pro-resolving properties; however, evidence regarding high-dose docosahexaenoic acid (DHA) supplementation remains inconclusive. This exploratory study investigated the effects of 16 weeks of DHA-rich PUFA supplementation (2.5 g/d DHA and 0.5 g/d EPA) on clinical, functional, and inflammatory outcomes in individuals with moderate RA. A modest sample size of thirteen women (23–61 y) were randomized to receive either n-3 PUFA (n = 7) or placebo (n = 6). Clinical outcomes, quality of life, functional performance, cardiometabolic parameters, and systemic inflammatory markers were assessed before and after the intervention. Additionally, the inflammatory response of peripheral blood mononuclear cells (PBMCs) exposed to patient serum collected before and after supplementation, with and without the n-3 PUFA mediator resolvin D1 (RvD1), was evaluated. DHA-rich PUFA supplementation significantly reduced morning stiffness duration and improved RA-specific quality of life scores, without affecting systemic inflammatory or cardiometabolic markers. Serum obtained after supplementation attenuated TNF-α expression in PBMCs and produced effects comparable to RvD1 treatment. These findings suggest that DHA-rich PUFA supplementation improves clinically relevant outcomes in RA, potentially through local pro-resolving mechanisms. Full article
(This article belongs to the Special Issue Application of Nutrition and Clinical Exercise Physiology)
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