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Application of Nutrition and Clinical Exercise Physiology

A Special Issue of Applied Sciences (ISSN 2076-3417) belonging to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (20 March 2026) | Viewed by 2084

Editors


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Guest Editor
Department of Bromatology, Poznan University of Medical Sciences, 60-806 Poznan, Poland
Interests: diet; food science; food analysis; nutrition and disease; nutrition and health

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Guest Editor
Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, 31-066 Kraków, Poland
Interests: diet; nutrition and health; lifestyle interventions

Special Issue Information

Dear Colleagues,

The contemporary approach to the prevention and treatment of lifestyle diseases is increasingly based on interdisciplinary strategies that include both a well-balanced diet and individually tailored physical activity. Clinical exercise physiology combined with nutrition science allows for a better understanding of the impact of these factors on the functioning of the body—both in healthy conditions and in the course of chronic diseases.

Topics include the use of dietary interventions and physical activity programmes in the treatment and prevention of metabolic, cardiovascular, respiratory, and autoimmune disorders. Equally important is the study of the mechanisms underlying these interventions, as well as their impact on quality of life, physical performance, body composition, and biochemical and hormonal parameters.

This Special Issue focuses on the practical and scientific aspects of the use of nutrition and exercise physiology in clinical practice and public health, encouraging the sharing of research results, literature reviews, and innovative therapeutic approaches.

Dr. Izabela Bolesławska
Dr. Pawel Jagielski
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • clinical exercise physiology
  • nutrition and health
  • lifestyle interventions
  • chronic disease prevention
  • physical activity in clinical practice
  • metabolic health

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Published Papers (2 papers)

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Review

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36 pages, 2512 KB  
Review
Physiological, Nutritional and Technological Approaches to Assessing Sarcopenia in Older Adults
by Marta Kończak, Izabela Bolesławska, Paweł Jagielski, Dominika Kusyk and Sławomira Drzymała-Czyż
Appl. Sci. 2026, 16(14), 7338; https://doi.org/10.3390/app16147338 - 22 Jul 2026
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Abstract
Sarcopenia is an age-related progressive decline in skeletal muscle mass, strength, and physical performance that increases the risk of falls, disability, and reduced quality of life among older adults. Its pathogenesis is multifactorial and involves chronic low-grade inflammation, hormonal disturbances, insulin resistance, and [...] Read more.
Sarcopenia is an age-related progressive decline in skeletal muscle mass, strength, and physical performance that increases the risk of falls, disability, and reduced quality of life among older adults. Its pathogenesis is multifactorial and involves chronic low-grade inflammation, hormonal disturbances, insulin resistance, and mitochondrial dysfunction, leading to an imbalance between muscle protein synthesis and degradation. The aim of this study was to summarise current knowledge regarding the mechanisms underlying sarcopenia, contemporary diagnostic methods, and the effectiveness of modern nutritional and exercise-based strategies, with particular emphasis on technologies supporting patient monitoring. This study is a structured narrative review conducted across PubMed, Scopus, and Web of Science databases, with the literature search completed on 1 March 2026. Separate searches were performed for thematic sections, including pathophysiology, diagnosis, physical activity, nutritional interventions, plant-derived compounds, and digital health technologies. While the core search focused on publications from 2023–2025, specific time-bound deviations were applied: the search for plant-derived compounds was extended back to 2020, and combined interventions were searched up to March 2026 to ensure the inclusion of the most recent evidence. The review included 53 peer-reviewed primary studies (RCTs and observational) and secondary literature (reviews and meta-analyses) involving individuals aged ≥60 years. The most robust evidence supports multicomponent interventions, particularly the synergy between resistance training and adequate protein intake (1.2–1.5 g/kg/day), often supplemented with leucine, vitamin D, omega-3 fatty acids, and creatine. Such strategies effectively counteract anabolic resistance by combining mechanical loading with the stimulation of the mTORC1 signalling pathway, leading to significant improvements in muscle mass, strength, and physical function. While isolated protein or micronutrient supplementation shows limited effectiveness in the absence of exercise, their role as supportive elements in multimodal strategies is well-documented. Furthermore, emerging digital health technologies—including wearable sensors and telerehabilitation—are proving essential for clinical practice, enabling precise, continuous monitoring of physical activity and gait parameters under free-living conditions, which enhances both patient adherence and long-term therapeutic outcomes. Full article
(This article belongs to the Special Issue Application of Nutrition and Clinical Exercise Physiology)
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14 pages, 988 KB  
Brief Report
DHA-Rich n-3 PUFA Supplementation Improves Morning Stiffness and Quality of Life in Patients with Rheumatoid Arthritis and Downregulates TNF-α Expression in PBMCs
by Alejandro A. Candia, Victoria Torres-Galaz, Camila Latapiatt, Denisse Valladares-Ide and Sebastián Jannas-Vela
Appl. Sci. 2026, 16(4), 1980; https://doi.org/10.3390/app16041980 - 17 Feb 2026
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Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease associated with joint pain, stiffness, functional impairment, and reduced quality of life. Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have been proposed as adjunctive therapies for RA due to their anti-inflammatory and pro-resolving properties; however, [...] Read more.
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease associated with joint pain, stiffness, functional impairment, and reduced quality of life. Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have been proposed as adjunctive therapies for RA due to their anti-inflammatory and pro-resolving properties; however, evidence regarding high-dose docosahexaenoic acid (DHA) supplementation remains inconclusive. This exploratory study investigated the effects of 16 weeks of DHA-rich PUFA supplementation (2.5 g/d DHA and 0.5 g/d EPA) on clinical, functional, and inflammatory outcomes in individuals with moderate RA. A modest sample size of thirteen women (23–61 y) were randomized to receive either n-3 PUFA (n = 7) or placebo (n = 6). Clinical outcomes, quality of life, functional performance, cardiometabolic parameters, and systemic inflammatory markers were assessed before and after the intervention. Additionally, the inflammatory response of peripheral blood mononuclear cells (PBMCs) exposed to patient serum collected before and after supplementation, with and without the n-3 PUFA mediator resolvin D1 (RvD1), was evaluated. DHA-rich PUFA supplementation significantly reduced morning stiffness duration and improved RA-specific quality of life scores, without affecting systemic inflammatory or cardiometabolic markers. Serum obtained after supplementation attenuated TNF-α expression in PBMCs and produced effects comparable to RvD1 treatment. These findings suggest that DHA-rich PUFA supplementation improves clinically relevant outcomes in RA, potentially through local pro-resolving mechanisms. Full article
(This article belongs to the Special Issue Application of Nutrition and Clinical Exercise Physiology)
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