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Novel Research on Radiotherapy and Oncology

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 191

Special Issue Editors


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Guest Editor
Department of Urology, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania
Interests: benign prostatic hyperplasia; bladder cancer; upper urinary tract urothelial cell carcinoma; prostate cancer; kidney cancer; testicular cancer

E-Mail Website
Guest Editor
Department of Urology, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania
Interests: urolithiasis; bladder cancer; prostate cancer; testicular cancer; urothelial cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of Applied Sciences focuses on Novel Research on Radiotherapy and Oncology, aiming to showcase cutting-edge advancements and interdisciplinary approaches in cancer treatment. We invite contributions exploring innovative radiotherapy techniques, such as proton therapy, immuno-radiotherapy, and image-guided radiotherapy, as well as research on novel drug development, personalized medicine, and the integration of artificial intelligence in oncology. This Issue seeks to foster collaboration and knowledge sharing among researchers, clinicians, and industry professionals to improve cancer outcomes and quality of life for patients.

Dr. Catalin Andrei Bulai
Dr. Dragos Georgescu
Guest Editors

Manuscript Submission Information

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Keywords

  • radiotherapy
  • oncology
  • cancer treatment
  • drug development
  • personalized medicine
  • artificial intelligence
  • translational research

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Published Papers (1 paper)

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Research

18 pages, 4509 KiB  
Article
Impact of Metallic Implants on Dose Distribution in Radiotherapy with Electrons, Photons, Protons, and Very-High-Energy Beams
by Nicole Kmec Bedri, Milan Smetana and Ladislav Janousek
Appl. Sci. 2025, 15(8), 4536; https://doi.org/10.3390/app15084536 - 20 Apr 2025
Viewed by 179
Abstract
Metallic implants in radiotherapy patients alter dose distributions due to their high density and unique composition, potentially compromising treatment precision. This study evaluates the effects of three metallic materials, Co-Cr-Mo alloy, titanium alloy, and stainless steel, on dose distribution across four radiotherapy modalities: [...] Read more.
Metallic implants in radiotherapy patients alter dose distributions due to their high density and unique composition, potentially compromising treatment precision. This study evaluates the effects of three metallic materials, Co-Cr-Mo alloy, titanium alloy, and stainless steel, on dose distribution across four radiotherapy modalities: 6 MV photons, 15 MeV electrons, 170 MeV protons, and very-high-energy electrons (100 and 150 MeV). Monte Carlo simulations in the TOol for PArticle Simulations Monte Carlo (TOPAS MC) generated percentage depth dose curves and dose profiles, with dosage data standardized to a reference point and uncertainties addressed via error propagation. Results revealed that the Co-Cr-Mo alloy produced the most significant alterations. For instance, at 100 MeV Very High Electron Energy (VHEE), the dose at a 15 cm depth was 34.57% lower than in water; 6 MV photons showed a 15.16% reduction, and the proton Bragg peak shifted 9.5 cm closer to the source. These pronounced changes along the central beam axis affected dose distributions anterior and posterior to the metal. A prostate cancer simulation further demonstrated considerable dose reduction with deeply embedded metallic implants. The findings underscore the critical impact of implant properties on radiotherapy dose distributions, emphasizing the need to integrate these factors into clinical protocols to improve dosimetric accuracy and treatment safety. Full article
(This article belongs to the Special Issue Novel Research on Radiotherapy and Oncology)
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