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Applied Sciences
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Optical Biomedical Imaging
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Optical Biomedical Imaging

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (20 January 2022) | Viewed by 7095

Special Issue Editor

Prof. Dr. Swapan K. Gayen

E-Mail Website
Guest Editor
Department of Physics, City College of New York, New York, NY 10031, USA
Interests: biomedical optical imaging; optical imaging and pulse propagation through turbid media; nanoscale photonic materials; tunable solid-state lasers; ultrafast lasers and spectroscopy; spectroscopy of impurity ion-doped solids; nonlinear optics

Special Issue Information

Dear Colleagues,

We are inviting submission to this Special Issue on Optical Biomedical Imaging.

This area of research has experienced rapid growth over the last three decades. This growth derives, in part, from light-based modalities being noninvasive, safe, and relatively inexpensive, with diagnostic potential. Interactions with biomedical media may change such salient features as intensity, wavelength, coherence, phase, polarization, and directionality, as well as pulse duration of a beam of light, and thus provide a basis for development of novel imaging modalities. Advances in light sources, detectors, modulation schemes, beam shaping approaches, and numerical algorithms are enabling development of imaging methods for probing diseases in different body organs. Optical coherence tomography has already made a transition to the bedside. Other modalities are at different stages of research and development. 

The intent of this Special Issue is to explore where we are and what the future holds in this exciting area of human health related research. To that end, we invite submissions involving new techniques, methods, applications, results, as well as review articles.

Prof. Dr. Swapan K. Gayen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Diffuse optical imaging and tomography
  • Optical coherence tomography
  • Nonlinear optical imaging: Multiphoton microscopy, higher harmonic generation approaches
  • Multimodal imaging
  • Photoacoustic imaging
  • Functional in vivo imaging
  • Brain, breast, and prostate imaging
  • High resolution neuroimaging
  • Nanoparticles and contrast agent enhanced imaging
  • Spectral imaging for tissue and cellular pathology

Published Papers (3 papers)

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Research

13 pages, 2893 KiB  
Article
Imaging the Human Thyroid Using Three-Dimensional Diffuse Optical Tomography: A Preliminary Study
by Tetsuya Mimura, Shinpei Okawa, Hiroshi Kawaguchi, Yukari Tanikawa and Yoko Hoshi
Appl. Sci. 2021, 11(4), 1670; https://doi.org/10.3390/app11041670 - 12 Feb 2021
Cited by 9 | Viewed by 2130
Abstract
Thyroid cancer is usually diagnosed by ultrasound imaging and fine-needle aspiration biopsy. However, diagnosis of follicular thyroid carcinomas (FTC) is difficult because FTC lacks nuclear atypia and a consensus on histological interpretation. Diffuse optical tomography (DOT) offers the potential to diagnose FTC because [...] Read more.
Thyroid cancer is usually diagnosed by ultrasound imaging and fine-needle aspiration biopsy. However, diagnosis of follicular thyroid carcinomas (FTC) is difficult because FTC lacks nuclear atypia and a consensus on histological interpretation. Diffuse optical tomography (DOT) offers the potential to diagnose FTC because it can measure tumor hypoxia, while image reconstruction of the thyroid is still challenging mainly due to the complex anatomical features of the neck. In this study, we attempted to solve this issue by creating a finite element model of the human neck excluding the trachea (a void region). By reconstruction of the absorption coefficients at three wavelengths, 3D tissue oxygen saturation maps of the human thyroid are obtained for the first time by DOT. Full article
(This article belongs to the Special Issue Optical Biomedical Imaging)
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16 pages, 1438 KiB  
Article
Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics
by Pankaj Singh, Prabodh Pandey, Shivam Shukla, Naren Naik and Asima Pradhan
Appl. Sci. 2020, 10(24), 8836; https://doi.org/10.3390/app10248836 - 10 Dec 2020
Cited by 4 | Viewed by 1698
Abstract
Fiber-optic probes are imperative for in-vivo diagnosis of cancer. Depending on the access to a diseased organ and the mutations one aims to sense, the probe designs vary. We carry out a detailed numerical study of the efficacy of the common probe geometries [...] Read more.
Fiber-optic probes are imperative for in-vivo diagnosis of cancer. Depending on the access to a diseased organ and the mutations one aims to sense, the probe designs vary. We carry out a detailed numerical study of the efficacy of the common probe geometries for epithelial cancer characterization based on spatially resolved reflectance data. As per the outcomes of this comparative study, a probe has been manufactured and using Monte Carlo look up table based inversion scheme, the absorption and scattering coefficients of the epithelium mimicking top layer have been recovered from noisy synthetic as well as experimental data. Full article
(This article belongs to the Special Issue Optical Biomedical Imaging)
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12 pages, 2454 KiB  
Article
Multi-modal Anterior Eye Imager Combining Ultra-High Resolution OCT and Microvascular Imaging for Structural and Functional Evaluation of the Human Eye
by Peng Xiao, Zhengyu Duan, Gengyuan Wang, Yuqing Deng, Qian Wang, Jun Zhang, Shanshan Liang and Jin Yuan
Appl. Sci. 2020, 10(7), 2545; https://doi.org/10.3390/app10072545 - 07 Apr 2020
Cited by 5 | Viewed by 2587
Abstract
To establish complementary information for the diagnosis and evaluation of ocular surface diseases, we developed a multi-modal, non-invasive optical imaging platform by combining ultra-high resolution optical coherence tomography (UHR-OCT) with a microvascular imaging system based on slit-lamp biomicroscopy. Our customized UHR-OCT module achieves [...] Read more.
To establish complementary information for the diagnosis and evaluation of ocular surface diseases, we developed a multi-modal, non-invasive optical imaging platform by combining ultra-high resolution optical coherence tomography (UHR-OCT) with a microvascular imaging system based on slit-lamp biomicroscopy. Our customized UHR-OCT module achieves an axial resolution of ≈2.9 μm in corneal tissue with a broadband light source and an A-line acquisition rate of 24 kHz with a line array CCD camera. The microvascular imaging module has a lateral resolution of 3.5 μm under maximum magnification of ≈187.5× with an imaging rate of 60 frames/s, which is sufficient to image the conjunctival vessel network and record the movement trajectory of clusters of red blood cells. By combining the imaging optical paths of different modules, our customized multi-modal anterior eye imaging platform is capable of performing real-time cross-sectional UHR-OCT imaging of the anterior eye, conjunctival vessel network imaging, high-resolution conjunctival blood flow videography, fluorescein staining and traditional slit-lamp imaging on a single device. With self-developed software, a conjunctival vessel network image and blood flow videography were further analyzed to acquire quantitative morphological and hemodynamics parameters, including vessel fractal dimensions, blood flow velocity and vessel diameters. The ability of our multi-modal anterior eye imager to provide both structural and functional information for ophthalmic clinical applications was demonstrated on a healthy human subject and a keratitis patient. Full article
(This article belongs to the Special Issue Optical Biomedical Imaging)
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