Artificial Intelligence in Biomedical Informatics
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Computing and Artificial Intelligence".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 12
Special Issue Editors
Interests: artificial intelligence and machine learning in healthcare; biomedical signal processing; personalized medicine
Interests: extended reality, serious games and virtual agents in healthcare; digital health
Interests: machine learning; deep learning; anomaly detection; generative models
Special Issue Information
Dear Colleagues,
Artificial intelligence (AI) is rapidly advancing the field of biomedical informatics by enabling efficient analysis and interpretation of large and complex biomedical data. These technologies have significantly improved the precision, speed, and accuracy of disease diagnosis while enabling the development of personalized and predictive models to optimize patient outcomes. In an era where healthcare systems are increasingly overwhelmed by massive volumes of biological and clinical data, the integration of AI and bioinformatics presents promising opportunities to enhance clinical decision-making and transform patient care. Digital twins—virtual replicas of patients or biological systems—are emerging as powerful tools for patient-specific modeling, monitoring, and treatment planning. Similarly, virtual agents operating in extended reality environments provide new opportunities for interactive healthcare delivery and rehabilitation.
We are pleased to invite you to contribute to this Special Issue, which focuses on AI applications in biomedical informatics that advance healthcare research, clinical decision-making, and personalized medicine.
This Special Issue aims to collect original research articles and reviews presenting novel AI methodologies and their biomedical applications, including translational innovations involving digital twins and virtual agents. Contributions addressing challenges such as data integration, explainability, interpretability, and ethical implications are also encouraged to foster the real-world impact of AI in biomedical informatics.
Research areas may include (but are not limited to) the following:
- Artificial intelligence in diagnosis, screening, and clinical decision support.
- Machine learning and deep learning for biomedical data and imaging analysis.
- Personalized and precision medicine.
- AI-based analysis of EEG and other biosignals in neurological disorders.
- Virtual agents and immersive environments (virtual reality/augmented reality/mixed reality) for healthcare: embodied conversational agents, AI-driven virtual humans, serious games for patient support, coaching, or rehabilitation.
- Integration of biosignals and affective computing for adaptive virtual interactions.
- AI-based development of digital twins for physiological systems, rehabilitation, chronic disease monitoring, and personalized treatment.
- Explainable artificial intelligence and model interpretability.
- Expert systems for clinical decision support.
- Embedded AI for biomedical systems.
Dr. Sabatina Criscuolo
Dr. Ersilia Vallefuoco
Dr. Andrea Pollastro
Dr. Luís Correia
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- artificial intelligence
- biomedical engineering
- machine learning
- deep learning
- medical imaging
- digital twins
- virtual agents
- extended reality (XR)
- explainable AI
- clinical decision support
- neurological disorders
- embodied conversational agents
- virtual human twin
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