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Applied Sciences
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Magnetic Nanomaterials for Drug Delivery and Therapy
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Magnetic Nanomaterials for Drug Delivery and Therapy

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 8814

Special Issue Editors

Prof. Dr. Stefan H. Bossmann

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Guest Editor
Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, USA
Interests: protease signatures for early cancer diagnostics and cancer therapy decisions; imaging of biophysical barriers in cancer/spectral imaging/micrometastases; advanced drug delivery and drug delivery materials
Special Issues, Collections and Topics in MDPI journals
Dr. Madumali Kalubowilage

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Guest Editor
Department of Chemistry, Kansas State University, Manhattan, KS 66506-0401, USA
Interests: liquid biopsies; biomaterials; MRI sensors; drug delivery

Special Issue Information

Dear Colleagues,

We would like to invite you to submit a manuscript to this Special Issue of Applied Sciences entitled “Magnetic Nanomaterials for Drug Delivery and Therapy”. Magnetic nanomaterials are constantly evolving towards higher complexity and, therefore, improved efficacy in drug delivery across the blood–brain barrier, to sites of infections, chronic inflammation, or tumors and metastases. Advances in material sciences will be the key to developing efficient drug delivery methodologies. These are urgently needed, because both, classic chemotherapy and conventional nanotherapy lead to significant collateral effects, mainly because they cannot deliver drugs efficiently across physiological barriers. Active transport to targeted areas is required to elude these barriers. There is a significant potential for synergy of nanoparticle-based physical therapies (e.g., hyperthermia or ultrasound) and chemotherapy or immunotherapy. However, to date they are widely unexplored. In this issue, nanomaterials-centered approaches to nanotherapy will be discussed. We sincerely hope for a wide variety of technically sound manuscripts in this exciting research area.

Prof. Dr. Stefan H. Bossmann
Dr. Madumali Kalubowilage
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Magnetic Nanoparticles
  • Drug Delivery
  • Chemotherapy
  • Physical Therapy
  • Targeted Therapy
  • Blood-Brain-Barrier
  • Infectious Disease
  • Chronic Inflammation
  • Solid Tumor

Published Papers (2 papers)

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Research

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16 pages, 4639 KiB  
Article
A Facile One-Pot Synthesis of Water-Soluble, Patchy Fe3O4-Au Nanoparticles for Application in Radiation Therapy
by Stefanie Klein, Jakob Hübner, Christina Menter, Luitpold V. R. Distel, Winfried Neuhuber and Carola Kryschi
Appl. Sci. 2019, 9(1), 15; https://doi.org/10.3390/app9010015 - 21 Dec 2018
Cited by 13 | Viewed by 3606
Abstract
A facile one-pot synthesis route for the preparation of water-soluble, biocompatible patchy Fe3O4-Au nanoparticles (Fe3O4-Au pNPs) was developed. Biocompatibility was attained through surface functionalization with 1-methyl-3-(dodecylphosphonic acid) imidazolium bromide. The morphology, composition, crystal structure and [...] Read more.
A facile one-pot synthesis route for the preparation of water-soluble, biocompatible patchy Fe3O4-Au nanoparticles (Fe3O4-Au pNPs) was developed. Biocompatibility was attained through surface functionalization with 1-methyl-3-(dodecylphosphonic acid) imidazolium bromide. The morphology, composition, crystal structure and magnetic properties of the Fe3O4-Au pNPs were investigated by conducting experiments with transmission electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction and superconducting quantum interference device, respectively. Internalization of the Fe3O4-Au pNPs by MCF-7 cells occurred via endocytosis. The performance of the Fe3O4-Au pNPs as X-ray radiosensitizer in tumor cells was compared with that of gold nanocluster and Fe3O4 NPs. For this reason, MCF-7, A549 and MCF-10A cells were loaded with the respective kind of nanoparticles and treated with X-rays at doses of 1, 2 or 3 Gy. The nanoparticle-induced changes of the concentration of the reactive oxygen species (ROS) were detected using specific assays, and the cell survival under X-ray exposure was assessed employing the clonogenic assay. In comparison with the gold nanocluster and Fe3O4 NPs, the Fe3O4-Au pNPs exhibited the highest catalytic capacity for ROS generation in MCF-7 and A549 cells, whereas in the X-ray-induced ROS formation in healthy MCF-10A cells was hardly enhanced by the Fe3O4 NPs and Fe3O4-Au pNPs. Moreover, the excellent performance of Fe3O4-Au pNPs as X-ray radiosensitizers was verified by the quickly decaying radiation dose survival curve of the nanoparticle-loaded MCF-7 and A549 cells and corroborated by the small values of the associated dose-modifying factors. Full article
(This article belongs to the Special Issue Magnetic Nanomaterials for Drug Delivery and Therapy)
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Review

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17 pages, 6417 KiB  
Review
Magnetic Nanomaterials for Magnetically-Aided Drug Delivery and Hyperthermia
by Madumali Kalubowilage, Katharine Janik and Stefan H. Bossmann
Appl. Sci. 2019, 9(14), 2927; https://doi.org/10.3390/app9142927 - 22 Jul 2019
Cited by 25 | Viewed by 4786
Abstract
Magnetic nanoparticles have continuously gained importance for the purpose of magnetically-aided drug-delivery, magnetofection, and hyperthermia. We have summarized significant experimental approaches, as well as their advantages and disadvantages with respect to future clinical translation. This field is alive and well and promises meaningful [...] Read more.
Magnetic nanoparticles have continuously gained importance for the purpose of magnetically-aided drug-delivery, magnetofection, and hyperthermia. We have summarized significant experimental approaches, as well as their advantages and disadvantages with respect to future clinical translation. This field is alive and well and promises meaningful contributions to the development of novel cancer therapies. Full article
(This article belongs to the Special Issue Magnetic Nanomaterials for Drug Delivery and Therapy)
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