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Raman Spectroscopy Techniques and Their Biomedical Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1476

Special Issue Editors


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Guest Editor
Department of Biomedical, Dental and Morphological and Functional Imaging Sciences, University of Messina, Via Consolare Valeria, 98125 Messina, Italy
Interests: Raman spectroscopy; biomedical application; medical imaging

Special Issue Information

Dear Colleagues,

Raman spectroscopy is a vibrational technique and relies on the inelastic scattering process of monochromatic light, usually from a laser in the visible, near-infrared, or near-ultraviolet range. Raman spectra provide highly specific fingerprints and give important information about molecular components in simple and complex samples. Nowadays, due to developments in Raman instrumentations and techniques, Raman Spectroscopy is important in the physical, biological, and medical sciences. In this Special Issue of Applied Sciences, we invite researchers and authors to submit their original research articles exploring recent advances and novel applications of Raman spectroscopy in biomedical science.

Dr. Barbara Testagrossa
Dr. Giuseppe Acri
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Raman spectroscopy
  • molecular vibration
  • SERS
  • Raman microscopy
  • biomedical application
  • vibrational spectroscopy
  • medical science

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Published Papers (1 paper)

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Research

19 pages, 4384 KiB  
Article
Microwave, Ultrasound-Assisted, and Room Temperature One-Pot Synthesis of Silver and Gold Colloids Using Beta-Cyclodextrin as a Reducing and Capping Agent for SERS Applications
by Cristian Iacovita, Valentin Toma, Nicoleta Simona Vedeanu, Rareș-Ionuț Știufiuc and Constantin Mihai Lucaciu
Appl. Sci. 2024, 14(18), 8215; https://doi.org/10.3390/app14188215 - 12 Sep 2024
Cited by 1 | Viewed by 978
Abstract
Cyclodextrins (CDs) are macrocycles that are well suited for forming inclusion complexes for surface-enhanced Raman scattering (SERS) detection of analytes due to their low Raman activity, which minimizes background SERS signals and enhances the detection of target molecules without interference. In this paper, [...] Read more.
Cyclodextrins (CDs) are macrocycles that are well suited for forming inclusion complexes for surface-enhanced Raman scattering (SERS) detection of analytes due to their low Raman activity, which minimizes background SERS signals and enhances the detection of target molecules without interference. In this paper, we systematically investigated the synthesis of both silver (Ag) and gold (Au) nanoparticles (NPs) using CDs as reducing and capping agents in a basic environment using microwave (MW), ultrasound (US), and room temperature (RT) synthesis. We found that replacing NaOH with K2CO3 as an alkaline environment almost doubles the size (from <10 nm to around 20 nm) of AgNPs in the MW-assisted synthesis. Synthesis using the US produces less stable particles due to the sample evolution after US irradiation. Ag (20 nm) and Au (11 nm) were successfully obtained at room temperature in the presence of CDs and K2CO3. All synthesized particles present SERS activity. CD capping allowed us to detect hydrophobic molecules like naphthalene and melamine. In the case of methylene blue, the CD capping prevents the changes induced in the SERS by a basic pH. We also demonstrate that the newly synthesized NPs can discriminate by SERS the propranolol enantiomers. Moreover, propranolol inclusion in CDs leads to a dramatic change in its SERS spectrum. Full article
(This article belongs to the Special Issue Raman Spectroscopy Techniques and Their Biomedical Applications)
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