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Advances in Materials for Biosensing and Biomedical Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 571

Special Issue Editors


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Guest Editor
Institute of Mechanics, Otto von Guericke University Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany
Interests: biomechanics; applied mechanics; biomaterials; materials engineering; computational techniques

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Guest Editor
INSA Hauts-de-France LAMIH CNRS, UMR 8201, Université Polytechnique Hauts-de-France, Valenciennes, France
Interests: additive manufacturing; finite element analysis; biosensing materials; smart materials

Special Issue Information

Dear Colleagues,

Recent advances in materials science have opened up new frontiers for biosensing and biomedical applications, enabling the development of highly sensitive, selective, and multifunctional platforms. Novel materials such as nanostructured metals, conductive polymers, graphene derivatives, and bio-inspired composites are increasingly integrated into sensors and devices to achieve enhanced detection performance, real-time monitoring, and improved biocompatibility. At the same time, smart and stimuli-responsive materials are finding applications in personalized medicine, regenerative therapies, and implantable systems, bridging the gap between engineering innovations and clinical needs.

This Special Issue, titled ‘Advances in Materials for Biosensing and Biomedical Applications’, aims to highlight recent progress in the design, synthesis, characterization, and application of advanced materials that contribute to healthcare and biomedical diagnostics. We welcome original research articles, reviews, and perspectives covering a broad spectrum of topics, including nanomaterials for biosensors, functional coatings for medical devices, bioelectronics, lab-on-a-chip platforms, and novel materials for therapeutic delivery. Contributions that demonstrate interdisciplinary approaches combining material science, biology, engineering, and medicine are particularly encouraged.

By bringing together experts from multiple fields, this Special Issue seeks to provide an overview of the state-of-the-art developments and to inspire new strategies for translating material innovations into impactful biomedical solutions.

Dr. Hasan Mhd Nazha
Prof. Dr. Yicha Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensing materials
  • biomedical applications
  • nanomaterials
  • smart materials
  • bioelectronics
  • lab-on-a-chip
  • regenerative medicine
  • biocompatibility
  • advanced functional materials

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Published Papers (1 paper)

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Research

27 pages, 4244 KB  
Article
Low-Voltage Blood Component Separation for Implantable Kidneys Using a Sawtooth Electrode and Negative Dielectrophoresis
by Hasan Mhd Nazha, Mhd Ayham Darwich, Al-Hasan Ali and Basem Ammar
Appl. Sci. 2026, 16(6), 2785; https://doi.org/10.3390/app16062785 - 13 Mar 2026
Viewed by 359
Abstract
Implantable artificial kidneys represent a promising alternative for patients with end-stage renal disease (ESRD), aiming to overcome the limitations of conventional dialysis through the integration of microfluidic and electrokinetic technologies. In this study, we present a sawtooth electrode microfluidic chamber that achieves blood [...] Read more.
Implantable artificial kidneys represent a promising alternative for patients with end-stage renal disease (ESRD), aiming to overcome the limitations of conventional dialysis through the integration of microfluidic and electrokinetic technologies. In this study, we present a sawtooth electrode microfluidic chamber that achieves blood cell separation via negative dielectrophoresis at a record-low operating voltage of 1.4 V, representing a fivefold reduction compared with rectangular electrode designs and supporting potential integration into implantable artificial kidney systems. A microfluidic chip incorporating an asymmetric sawtooth electrode geometry was developed to enhance local electric field gradients while reducing power consumption. Device performance was investigated using COMSOL Multiphysics simulations. Response Surface Methodology (RSM) based on a Box–Behnken design was employed to optimize the number of teeth per unit length (N), sawtooth height (H), and applied voltage (V), while excitation frequency was fixed at 1 MHz and flow velocity was maintained constant at 0.1 µL·min−1. Statistical analysis was conducted using analysis of variance (ANOVA) in Minitab (Version 27; Minitab, LLC, State College, PA, USA, 2024). The optimization model showed strong predictive capability (R2 = 95.8%) and identified applied voltage (59.45% contribution) and sawtooth height (33%) as the dominant factors affecting separation efficiency, with a significant H × V interaction (p = 0.023). Comprehensive voltage-response mapping over the range of 0.8–4.0 V revealed four operational regimes, including a previously unreported high-voltage failure zone above 2.8 V, where electrothermal flow and electroporation degrade performance. Under physiological conductivity conditions, the optimized design maintained a separation efficiency of 78.3% at 1.4 V with a tip temperature rise of only 1.2 °C, while full recovery of performance was achieved at 2.2 V. Cell-specific separation efficiencies reached 97.3% for white blood cells, 95.8% for red blood cells, and 84.7% for platelets, reducing the downstream cellular load by 92.6%. These findings demonstrate that the proposed low-voltage, high-efficiency separation platform has strong potential as a cellular pre-filtration module in implantable artificial kidney systems and other lab-on-chip biomedical devices. Full article
(This article belongs to the Special Issue Advances in Materials for Biosensing and Biomedical Applications)
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