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Sustainable Nanomaterials for Biotechnological and Medical Applications: Current Developments

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 631

Special Issue Editors


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Guest Editor
CONAHCYT, Autonomous University of Coahuila, Saltillo 25280, CP, Mexico
Interests: nanoscience; nanobiotechnology; magnetic nanomaterials for biotechnological applications

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Guest Editor
Nanobioscience Research Group, School of Chemistry, Universidad Autónoma de Coahuila, Boulevard Venustiano Carranza e Ing. José Cárdenas Valdés s/n Col. República, Saltillo 25280, Mexico
Interests: nanoparticles and microparticles; nanoscience; nanobiotechnology

Special Issue Information

Dear Colleagues,

Nanotechnology is transforming medicine, leading to innovations such as drug delivery, diagnostics, and improved therapies for illnesses such as hyperthermia. Additionally, the application of nanomaterials in biotechnology is leading to improvements in this field. Developing sustainable nanomaterials through green synthesis methods and focusing on biocompatibility is essential to address these concerns. These materials are crucial for the future applications of medical and biotechnological improvements.

This Special Issue aims to gather cutting-edge research findings and comprehensive reviews on the current progress in the application of nanomaterials in the fields of biotechnology and medicine, with particular attention being paid to green methods of synthesis, the enhanced biocompatibility of nanomaterials, and efficiency in practical applications. This compilation of articles aims to provide insights into the future path of nanotechnology in these crucial areas.

In this Special Issue, we invite submissions of original research and review papers that explore various themes, including, but not limited to, the following:

  • Green synthesis of nanomaterials;
  • Biocompatibility and toxicity studies of sustainable nanomaterials;
  • Nanomaterials in biotechnological applications;
  • Applications of nanomaterials in drug delivery and hyperthermia systems;
  • Nanomaterials for bio-imaging and diagnostic tools;
  • Nanotechnology in tissue engineering and regenerative medicine;
  • Advances in nanomaterial-based biosensors.

Please feel free to submit your work for consideration in this Special Issue.

Dr. Rodolfo Ramos-González
Dr. Anna Ilyina
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sustainable nanomaterials
  • biotechnology
  • medicine
  • green synthesis
  • drug delivery
  • hyperthermia
  • bio-imaging
  • tissue engineering
  • regenerative medicine
  • biosensors
  • environmental impact

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Published Papers (1 paper)

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Research

23 pages, 8079 KiB  
Article
Electrophoretic Deposition of Green-Synthesized Hydroxyapatite on Thermally Oxidized Titanium: Enhanced Bioactivity and Antibacterial Performance
by Mariana Relva, Daniela Santo, Ricardo Alexandre, Pedro Faia, Sandra Carvalho, Zohra Benzarti and Susana Devesa
Appl. Sci. 2025, 15(15), 8598; https://doi.org/10.3390/app15158598 - 2 Aug 2025
Viewed by 215
Abstract
Titanium alloys such as Ti-6Al-4V are widely used in biomedical implants due to their excellent mechanical properties and biocompatibility, but their bioinert nature limits osseointegration and antibacterial performance. This study proposes a multifunctional surface coating system integrating a thermally oxidized TiO2 interlayer [...] Read more.
Titanium alloys such as Ti-6Al-4V are widely used in biomedical implants due to their excellent mechanical properties and biocompatibility, but their bioinert nature limits osseointegration and antibacterial performance. This study proposes a multifunctional surface coating system integrating a thermally oxidized TiO2 interlayer with a hydroxyapatite (HAp) top layer synthesized via a green route using Hylocereus undatus extract. The HAp was deposited by electrophoretic deposition (EPD), enabling continuous coverage and strong adhesion to the pre-treated Ti-6Al-4V substrate. Structural, morphological, chemical, and electrical characterizations were performed using XRD, SEM, EDS, Raman spectroscopy, and impedance spectroscopy. Bioactivity was assessed through apatite formation in simulated body fluid (SBF), while antibacterial properties were evaluated against Staphylococcus aureus. The results demonstrated successful formation of crystalline TiO2 (rutile phase) and calcium-rich HAp with good surface coverage. The HAp-coated surfaces exhibited significantly enhanced bioactivity and strong antibacterial performance, likely due to the combined effects of surface roughness and the bioactive compounds present in the plant extract. This study highlights the potential of eco-friendly, bio-inspired surface engineering to improve the biological performance of titanium-based implants. Full article
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