Special Issue "Applications of Green Nanomaterials in Biomedical Treatment"

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: 20 January 2022.

Special Issue Editors

Dr. Greta Varchi
E-Mail Website
Guest Editor
Institute of Organic Synthesis and Photoreactivity – Italian National Research Council, 40129 Bologna, Italy
Interests: anticancer drugs; photodynamic therapy; nanomedicine; drug delivery; biocompatible and bio-based nanoparticles; smart molecular conjugates; antimicrobial PDT; biomaterials
Special Issues and Collections in MDPI journals
Dr. Claudia Ferroni
E-Mail Website
Guest Editor
The Institute of Organic Synthesis and Photoreactivity (ISOF), Department of Chemical Sciences and Materials Technologies (DSCTM), National Research Council of Italy (CNR), 40129 Bologna, Italy
Interests: drug discovery; drug delivery; organic chemistry; nanomedicine; targeted therapy; cancer treatment

Special Issue Information

Dear Colleagues,

In the field of nanotechnology, the development of safe, ecofriendly nanomaterials is currently encountering growing interest due to the promising properties of these compounds, such as biocompatibility, biodegradability, and non-toxicity, as well as non-immunogenic behavior. During recent years, different “green” materials, such as fibroin, keratin, gelatin, chitosan, zein, and soy proteins, have been extensively investigated in order to develop ideal candidates for various biomedical applications. Indeed, current research for novel nanomaterials has had increasing focus on renewable and biodegradable proteins, polysaccharides, and lipids or their combinations for the production of effective and versatile nano-biomedical systems for the treatment of different pathologies.

The aim of this Special Issue of Applied Sciences is to collect full-length articles, reviews and communications on the development, characterization (including biological), and potential wide range of applications of green nanomaterials, including imaging, drug delivery, antimicrobial treatment, and tissue engineering. Particular attention will be given to the use of low-cost and environmentally friendly procedures for nanoparticle preparation.

Dr. Greta Varchi
Dr. Claudia Ferroni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • eco-friendly procedures
  • biomedical applications
  • targeted therapy
  • chemotherapy
  • multimodal strategies
  • imaging
  • theranostic systems

Published Papers (3 papers)

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Research

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Article
Biomimetic Amorphous Titania Nanoparticles as Ultrasound Responding Agents to Improve Cavitation and ROS Production for Sonodynamic Therapy
Appl. Sci. 2020, 10(23), 8479; https://doi.org/10.3390/app10238479 - 27 Nov 2020
Cited by 2 | Viewed by 709
Abstract
Conventional therapies to treat cancer often exhibit low specificity, reducing the efficiency of the treatment and promoting strong side effects. To overcome these drawbacks, new ways to fight cancer cells have been developed so far focusing on nanosystems. Different action mechanisms to fight [...] Read more.
Conventional therapies to treat cancer often exhibit low specificity, reducing the efficiency of the treatment and promoting strong side effects. To overcome these drawbacks, new ways to fight cancer cells have been developed so far focusing on nanosystems. Different action mechanisms to fight cancer cells have been explored using nanomaterials, being their remote activation one of the most promising. Photo- and sonodynamic therapies are relatively new approaches that emerged following this idea. These therapies are based on the ability of specific agents to generate highly cytotoxic reactive oxygen species (ROS) by external stimulation with light or ultrasounds (US), respectively. Crystalline (TiO2) and amorphous titania (a-TiO2) nanoparticles (NPs) present a set of very interesting characteristics, such as their photo-reactivity, photo stability, and effective bactericidal properties. Their production is inexpensive and easily scalable; they are reusable and demonstrated already to be nontoxic. Therefore, these NPs have been increasingly studied as promising photo- or sonosensitizers to be applied in photodynamic/sonodynamic therapies in the future. However, they suffer from poor colloidal stability in aqueous and biological relevant media. Therefore, various organic and polymer-based coatings have been proposed. In this work, the role of a-TiO2 based NPs synthesized through a novel, room-temperature, base-catalyzed, sol-gel protocol in the generation of ROS and as an enhancer of acoustic inertial cavitation was evaluated under ultrasound irradiation. A novel biomimetic coating based on double lipidic bilayer, self-assembled on the a-TiO2-propylamine NPs, is proposed to better stabilize them in water media. The obtained results show that the biomimetic a-TiO2-propylamine NPs are promising candidates to be US responding agents, since an improvement of the cavitation effect occurs in presence of the developed NPs. Further studies will show their efficacy against cancer cells. Full article
(This article belongs to the Special Issue Applications of Green Nanomaterials in Biomedical Treatment)
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Article
Microbial Mediated Synthesis of Silver Nanoparticles by Lactobacillus Plantarum TA4 and its Antibacterial and Antioxidant Activity
Appl. Sci. 2020, 10(19), 6973; https://doi.org/10.3390/app10196973 - 05 Oct 2020
Cited by 4 | Viewed by 995
Abstract
The present study aimed to investigate the ability of Lactobacillus plantarum TA4 in tolerating Ag+ and its ability to produce silver nanoparticles (AgNPs). The biosynthesized AgNPs were characterized using UV–Visible spectroscopy (UV–Vis), dynamic light scattering (DLS), Fourier-transform infrared (FTIR), and high-resolution transmission [...] Read more.
The present study aimed to investigate the ability of Lactobacillus plantarum TA4 in tolerating Ag+ and its ability to produce silver nanoparticles (AgNPs). The biosynthesized AgNPs were characterized using UV–Visible spectroscopy (UV–Vis), dynamic light scattering (DLS), Fourier-transform infrared (FTIR), and high-resolution transmission electron microscope (HR-TEM). The cell biomass of L. plantarum TA4 demonstrated the ability to tolerate Ag+ at a concentration of 2 mM, followed by the formation of AgNPs. This was confirmed by the visual observation of color changes and a presence of maximum UV–Vis absorption centered at 429 nm. HR-TEM analysis revealed that the AgNPs were spherical with an average size of 14.0 ± 4.7 nm, while the SEM-EDX analysis detected that the particles were primarily located on the cell membrane of L. plantarum TA4. Further, DLS analysis revealed that the polydispersity index (PDI) value of biosynthesized AgNPs was 0.193, implying the monodispersed characteristic of NPs. Meanwhile, the FTIR study confirmed the involvement of functional groups from the cell biomass that involved in the reduction process. Moreover, biosynthesized AgNPs exhibited antibacterial activity against Gram-positive and Gram-negative pathogens in a concentration-dependent manner. Furthermore, the antioxidant property of biosynthesized AgNPs that was evaluated using the DPPH assay showed considerable antioxidant potential. Results from this study provide a sustainable and inexpensive method for the production of AgNPs. Full article
(This article belongs to the Special Issue Applications of Green Nanomaterials in Biomedical Treatment)
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Review

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Review
Green Approaches to Carbon Nanostructure-Based Biomaterials
Appl. Sci. 2021, 11(6), 2490; https://doi.org/10.3390/app11062490 - 11 Mar 2021
Cited by 4 | Viewed by 1053
Abstract
The family of carbon nanostructures comprises several members, such as fullerenes, nano-onions, nanodots, nanodiamonds, nanohorns, nanotubes, and graphene-based materials. Their unique electronic properties have attracted great interest for their highly innovative potential in nanomedicine. However, their hydrophobic nature often requires organic solvents for [...] Read more.
The family of carbon nanostructures comprises several members, such as fullerenes, nano-onions, nanodots, nanodiamonds, nanohorns, nanotubes, and graphene-based materials. Their unique electronic properties have attracted great interest for their highly innovative potential in nanomedicine. However, their hydrophobic nature often requires organic solvents for their dispersibility and processing. In this review, we describe the green approaches that have been developed to produce and functionalize carbon nanomaterials for biomedical applications, with a special focus on the very latest reports. Full article
(This article belongs to the Special Issue Applications of Green Nanomaterials in Biomedical Treatment)
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