Exploitation of Microbial Metabolites and Novel Approaches of Their Synthesis

Dear Colleagues,

Microbial metabolites such as antibiotics, pigments, aroma compounds, hormones, drug agents, antimicrobials, antioxidants and enzymes are of great interest due to their huge potential for human life and health. Among the microorganisms producing the above-mentioned compounds, there can be enumerated archeabacteria, bacteria, yeast, molds and algae. Bioactive compounds have their action in small amounts and are still being investigated in medicine, chemistry, food technology and ecology. We hardly know a small percentage of all organisms living on earth. Moreover, we search for so-called extremophiles. These microorganisms can, in contrast to mesophiles, grow under extreme conditions. It can be imagined that such organisms either produce a different range of enzymes than mesophiles, or produce enzymes with extreme characteristics, such as temperature or stability and activity at extreme pH values. Exploiting new microorganisms is not the only way of possessing new metabolites; recombinant DNA techniques may open the door to the application of microbial bioactive compounds. Still, introducing new bioprocessing techniques can be a promising idea to synthesize with higher yield microbial-derived biologically active molecular entities.

This Special Issue welcomes papers addressing the different effects that exposure studies on new microbial metabolites, metabolites already known from newly discovered or engineered cells or microbial metabolites with improved yield by novel methodology of culture.

Dr. Agata Urszula Fabiszewska
Guest Editor

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• microbial metabolites
• genetic manipulation
• batch culture
• novel resources
• green chemistry