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Bioactive Glass Nanoparticles: From Synthesis to Materials Design for Biomedical...
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Bioactive Glass Nanoparticles: From Synthesis to Materials Design for Biomedical Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 5982

Special Issue Editor

Prof. Dr. Elia Marin

E-Mail Website
Guest Editor
Department of Material Chemistry, Kyoto Institute of Technology, Kyoto 606-8585, Japan
Interests: bioactive materials; materials characterization; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my great pleasure to announce the opening of a new Special Issue in the Applied Science journal.

This issue will focus on the design, synthesis, characterization and application of Bioactive Glass Nanoparticles with a particular focus on their biomedical uses. Bioactive glasses represent one of the most successful categories of biomedical materials: since their initial formulation, back in the late 1960s, they have known a constant evolution in chemical composition and structure and have been successfully applied for both hard and soft tissue repair and engineering. Bioactive Glass Nanoparticles represent a natural evolution for the “bulk” bioactive glasses, where the scarce mechanical properties have been completely sacrificed to optimize the surface area and thus further increase bioactivity.

The aim of this Special Issue is to contribute to this field and offer a comprehensive overview of both technological advances and applications.

Proposed topics include, but are not limited to

  • Top-down processing of nanoparticles;
  • Sol-gel synthesis processes;
  • Innovative production methods;
  • Nano-porous drug delivery systems;
  • Nanoparticles-reinforced composite materials;
  • Implant coating strategies;
  • Nanoparticles dispersions for dentistry and wound healing;
  • Antibacterial effects of bioactive glass nanoparticles and related materials;
  • Biological activity of nanoparticles-based materials.

I hope you will join us and contribute to the success of this Special Issue by submitting the latest results of your research in this interesting field.

Prof. Elia Marin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioactive glass nanoparticles
  • Bioglass
  • Nanoparticles
  • Biomaterials
  • Drug delivery
  • Tissue repair
  • Antibacterial
  • Nanomaterials

Published Papers (2 papers)

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Research

10 pages, 3121 KiB  
Article
Bioactive Glass as a Nanoporous Drug Delivery System for Teicoplanin
by Chih-Ling Huang, Wei Fang, Bo-Rui Huang, Yan-Hsiung Wang, Guo-Chung Dong and Tzer-Min Lee
Appl. Sci. 2020, 10(7), 2595; https://doi.org/10.3390/app10072595 - 09 Apr 2020
Cited by 10 | Viewed by 3176
Abstract
Bioactive glass (BG) was made by the sol–gel method and doped with boron (B) to increase its bioactivity. Microstructures of BG and B-doped BG were observed by scanning electron microscopy, and phase identification was performed using an X-ray diffraction diffractometer. The ion concentrations [...] Read more.
Bioactive glass (BG) was made by the sol–gel method and doped with boron (B) to increase its bioactivity. Microstructures of BG and B-doped BG were observed by scanning electron microscopy, and phase identification was performed using an X-ray diffraction diffractometer. The ion concentrations released after soaking in simulated body fluid (SBF) for 1, 4, and 7 days were measured by inductively coupled plasma mass spectrometry, and the pH value of the SBF was measured after soaking samples to determine the variation in the environment. Brunauer–Emmett–Teller (BET) analysis was performed to further verify the characteristics of mesoporous structures. High performance liquid chromatography was used to evaluate the drug delivery ability of teicoplanin. Results demonstrated that B-doped BG performed significantly better than BG in parameters assessed by the BET analysis. B-doped BG has nanopores and more rough structures, which is advantageous for drug delivery as there are more porous structures available for drug adsorption. Moreover, B-doped BG was shown to be effective for keeping pH values stable and releasing B ions during soaking in SBF. The cumulative release of teicoplanin from BG and B-doped BG reached 20.09% and 3.17% on the first day, respectively. The drug release gradually slowed, reaching 29.43% and 4.83% after 7 days, respectively. The results demonstrate that the proposed bioactive glass has potential as a drug delivery system. Full article
(This article belongs to the Special Issue Bioactive Glass Nanoparticles: From Synthesis to Materials Design for Biomedical Applications)
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16 pages, 4072 KiB  
Article
In Vitro Effect of Gallium-Doped Bioactive Glass on Enamel Anti-Demineralization and Bond Strength of Orthodontic Resins
by Hyo-Kyung Song, Kyung-Hyeon Yoo, Seog-Young Yoon, Hee Sam Na, Jin Chung, Woo-Sung Son, Seung-Min Lee and Yong-Il Kim
Appl. Sci. 2019, 9(22), 4918; https://doi.org/10.3390/app9224918 - 15 Nov 2019
Cited by 13 | Viewed by 2410
Abstract
White spot lesions (WSL) that occur on teeth after orthodontic appliances have been attached are caused by bacterial demineralization of the enamel surface. This study investigated the anti-demineralization effect of orthodontic resins containing mesoporous bioactive glass nanoparticles (MBN) doped with gallium, which has [...] Read more.
White spot lesions (WSL) that occur on teeth after orthodontic appliances have been attached are caused by bacterial demineralization of the enamel surface. This study investigated the anti-demineralization effect of orthodontic resins containing mesoporous bioactive glass nanoparticles (MBN) doped with gallium, which has antibacterial activity, as well as MBN with increased calcium and phosphate contents as these ions can remineralize enamel. Resins (CF, CharmFill Flow, Dentkist, Seoul, South Korea) containing 1%, 3%, and 5% Ga-doped MBN (GaMBN) were characterized using scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and isothermal tests, and their physical properties were measured in terms of Vickers microhardness, bracket retention force, and adhesive remnant index (ARI). Cell viability in the resins was confirmed by testing human dental pulp stem cells (hDPSCs), and ion release tests were performed after 1, 7, and 14 days to determine whether the resins released Ga3+, Ca2+, and PO43–. After 14 days, antibacterial activity was determined using Streptococcus mutans (S. mutans)—the bacteria that causes tooth decay—and the chemical remineralization effect was investigated using a cycle of acid–base solutions. The microhardness of the resins increased with GaMBN concentration whereas their bracket retention force, ARI, and cell viability remained unchanged. The bacterial activity of the 5%-GaMBN resin decreased after 24 and 48 h; however, the change in activity was not statistically significant. Anti-demineralization testing demonstrated that the degree of enamel demineralization decreased as the GaMBN concentration increased, which indicates that resins containing 5%-GaMBN may be viable orthodontic adhesives for preventing WSLs. Full article
(This article belongs to the Special Issue Bioactive Glass Nanoparticles: From Synthesis to Materials Design for Biomedical Applications)
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