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Radiation Physics: Advances in DNA and Cellular Technologies

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1156

Special Issue Editors


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Guest Editor
RST/Applied Radiation & Isotopes, Applied Sciences, Delft University of Technology, PO Box 5, 2600 AA Delft, The Netherlands
Interests: Monte Carlo simulations; Geant4-DNA; GATE; radiation biology

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Guest Editor
Istituto Nazionale di Fisica Nucleare (INFN), Laboratori Nazionali del Sud (LNS), Catania, Italy
Interests: Monte Carlo simulations; Geant4, track-structure simulations; Geant4-DNA; radiobiology; radiochemistry

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Guest Editor
Medical Physics Laboratory Department of Medicine, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece
Interests: radiation interactions; Monte Carlo radiation transport; microdosimetry; radiobiological modeling; radiation protection; Geant4; Geant4-DNA
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan
Interests: Geant4-DNA; Geant4; nuclear/radiation physics; radiation biology; radiation detection; dosimetry; medical physics

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Guest Editor
Vinca Institute of Nuclear Sciences—National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia
Interests: biophysics; radiation biology; Geant4 and Geant4-DNA studies

Special Issue Information

Dear Colleagues,

DNA damage studies are of growing interdisciplinary interest, spanning fields such as radio-protection, radiotherapy, and space mission research.

These investigations rely on modeling radiation interactions with matter at the nanoscale, incorporating not only the underlying physics but also the resulting chemical reactions and biological repair mechanisms.
To explore this complex research area, significant computational advancements have been made over the past decades, leading to the development of track-structure Monte Carlo tools capable of simulating various aspects of this intricate process. Notable examples include Geant4-DNA, GATE, PARTRAC, RITRACKS, TOPAS, TRAX-CHEM, CHEM-KURBUC, and IONLYS-IRT.

This Special Issue aims to gather articles on recent progress in DNA damage modeling across diverse fields of applications, including radiobiology, radiochemistry, medicine, and space radiation research, with a focus on improving our understanding of DNA damage and its biological consequences.

Dr. Konstantinos Chatzipapas
Dr. Serena Fattori
Dr. Ioanna Kyriakou
Dr. Dousatsu Sakata
Dr. Milos Dordevic
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • radiation transport
  • Monte Carlo simulations
  • DNA damage
  • Monte Carlo simulation
  • radiation interaction
  • track structure modeling
  • radioprotection
  • radiotherapy
  • space radiation
  • chemical reactions
  • biological repair mechanisms
  • radiobiology

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Published Papers (1 paper)

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Research

21 pages, 6776 KB  
Article
X-Ray-Induced Alterations in In Vitro Blood–Brain Barrier Models: A Comparative Analysis
by Roberta Moisa (Stoica), Stela Rodica Lucia Pătrașcu, Călin Mircea Rusu, Mihail Răzvan Ioan, Mihai Radu and Beatrice Mihaela Radu
Appl. Sci. 2026, 16(2), 587; https://doi.org/10.3390/app16020587 - 6 Jan 2026
Viewed by 554
Abstract
Ionizing radiation remains the primary approach for treating brain cancer and is frequently used in combination with chemotherapy. However, when it comes to gliomas, the effective delivery of therapeutic agents is hindered by the limited permeability of the blood–brain barrier (BBB). Consequently, selecting [...] Read more.
Ionizing radiation remains the primary approach for treating brain cancer and is frequently used in combination with chemotherapy. However, when it comes to gliomas, the effective delivery of therapeutic agents is hindered by the limited permeability of the blood–brain barrier (BBB). Consequently, selecting the most suitable and least harmful type of ionizing radiation is essential, given its potential side effects on healthy cells within the tumor microenvironment. In this study, we explored the impact of X-ray exposure on two in vitro BBB endothelial cell models—murine and human. Post-irradiation, we evaluated cell viability, clonogenic capacity, cell cycle progression, reactive oxygen species (ROS) levels, formation of micronuclei and γ-H2AX foci, as well as alterations in cytoskeletal organization, cell migration, and intracellular calcium dynamics. The results demonstrate notable differences between the two endothelial cell lines, suggesting the human cell line is more sensitive to X-rays. In conclusion, our study provides valuable insights into the brain microvascular endothelial cells’ response to radiation, laying the groundwork for strategies to protect healthy brain tissue. Full article
(This article belongs to the Special Issue Radiation Physics: Advances in DNA and Cellular Technologies)
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