Nanostructured and Functionalized Materials: Characterization and Applications II

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: closed (20 November 2023) | Viewed by 1397

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Department of Materials Science, Transilvania University of Brasov - Romania, 29 Eroilor blvd., 500036 Brasov, Romania
Interests: surface engineering (diffusion processes, coatings and thin-films deposition, surfaces tribology); solid-phase transformation; heat treatment; materials characterization
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Special Issue Information

Dear Colleagues,

We are inviting you to submit your recent research work to a forthcoming Special Issue on “Nanostructured and Functionalized Materials: Characterization and Applications”.

This Special Issue will cover recent research results in functionalized materials, including a wide range of length scales, from the nano-level to the macroscopic level. Research works providing results on nanostructured material synthesis, processing and manipulation, or macroscopic fabrication of bulk materials, surfaces, and nanocomposites are expected and welcome. Moreover, in terms of applications, we will also consider papers that cover topics including (but not limited to): biomedical applications, mechanical and tribological applications, optical and decorative applications, energy applications, and so on.

Prof. Dr. Daniel Munteanu
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Published Papers (1 paper)

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Research

15 pages, 5425 KiB  
Article
Influence of the Polymer and Solvent Variables on the Nanoencapsulation of the Flavonoid Quercetin: Preliminary Study Based on Eudragit® Polymers
by Joel H. Elizondo-Luevano, Rocío Castro-Ríos, Roberto Parra-Saldívar, Horacio Larqué-García, Marsela Garza-Tapia, Elda M. Melchor-Martínez and Abelardo Chávez-Montes
Appl. Sci. 2023, 13(13), 7816; https://doi.org/10.3390/app13137816 - 3 Jul 2023
Cited by 3 | Viewed by 1145
Abstract
Eudragit® polymers have proven their potential as a means to control the release of aqueous insoluble drugs in various delivery systems as polymer nanoparticles (PNPs). The size (S) and polydispersity index (PDI) of PNPs are crucial factors for their interaction with biological [...] Read more.
Eudragit® polymers have proven their potential as a means to control the release of aqueous insoluble drugs in various delivery systems as polymer nanoparticles (PNPs). The size (S) and polydispersity index (PDI) of PNPs are crucial factors for their interaction with biological systems from a pharmaceutical standpoint. This study aimed to determine the impact of the volumes of the organic phase (OP) and aqueous phase (AP), as well as the polymer amount (PA), on the size and PDI of PNPs prepared using the nanoprecipitation method for encapsulating quercetin (Qr). The study also evaluated the toxic effects of PNPs on human erythrocytes. The PNPs were prepared using preformed polymers derived from methacrylic acid and polyvinyl alcohol (PVA) as a surfactant. The nanoprecipitation technique enabled the production of particles smaller than 200 nm with a PDI lower than 0.2, and the study established the significant impact (p < 0.05) of the three variables related to the polymers and solvents. The selected PNPs contained 5 mg of Qr and 50 mg of Eudragit polymers (1:10 w/w Eudragit® EPO, E100, L100, and Eudragit L100-55) and diverse concentrations of PVA. The study found that including PVA in the AP increased the Qr encapsulation by up to 98%. The hemolytic potential of Eudragit® PNPs and Qr was assessed in human erythrocytes, with no significant cytotoxic activity observed (p < 0.001) compared with the control. In conclusion, via the nanoprecipitation technique, preparing PNPs with defined and homogeneous S to entrap the flavonol Qr efficiently is possible. Full article
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