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A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 5561

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Editors

Dr. Francesca Gazzani

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Guest Editor

Department of Health Science, UniCamillus-Saint Camillus International Medical University, 00131 Rome, Italy
Interests: orthodontics; orthodontic treatment and diagnosis; interceptive treatment; materials in orthodontics

Prof. Dr. Roberta Lione

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Guest Editor

Special Issue Information

Dear Colleagues,

The field of dental materials is undergoing rapid innovation, driven by the increasing demand for biocompatibility, mechanical strength, aesthetic performance, and long-term durability. This Special Issue, Recent Advancements in Novel Dental Materials, aims to highlight the latest developments in material science as applied to dentistry, including but not limited to restorative, adhesive, prosthetic, endodontic, and orthodontic applications. Special emphasis will be placed on advanced resin composites, nanomaterials, bioactive and biomimetic materials, smart materials, and novel fabrication techniques. We welcome contributions that explore the mechanical, physical, biological, and clinical properties of new dental materials, as well as studies addressing their in vitro and in vivo performance, long-term stability, and sustainability. Original research articles, reviews, and case-based studies are all invited to provide a comprehensive overview of cutting-edge materials that will shape the future of modern dentistry.

Dr. Francesca Gazzani
Prof. Dr. Roberta Lione
Guest Editors

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Keywords

dental materials
resin composites
materials in orthodontic treatment
nanotechnology
3D imaging in dentistry
mechanical properties
adhesion and wear analysis
stripping tecnhicques

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Published Papers (3 papers)

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Research

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16 pages, 902 KB

Open AccessArticle

Regenerative Endodontic Treatment with Calcium Hydroxide-Assisted Blood Clot Stabilisation in Traumatised Immature Teeth: A Retrospective Study of Clinical and Radiographic Outcomes

by Petra Bučević Sojčić, Domagoj Glavina, Jakov Stojanović, Jelena Bagarić, Dubravka Turjanski, Tomislav Škrinjarić, Kristina Goršeta and Hrvoje Jurić

Appl. Sci. 2026, 16(10), 5158; https://doi.org/10.3390/app16105158 - 21 May 2026

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Abstract

Traumatised immature permanent teeth with pulp necrosis pose a clinical challenge due to incomplete root development and limited treatment options. This retrospective observational study evaluated the clinical and radiographic outcomes of regenerative endodontic treatment (RET) incorporating an additional calcium hydroxide-based step for blood clot stabilisation compared with apexification in traumatised immature teeth. A total of 49 teeth treated between 2015 and 2025 were analysed. Clinical and radiographic parameters were recorded at baseline and reassessed at 6- and 12-month follow-up, including root length, dentinal wall thickness, apical diameter, periapical status, and apical closure. RET was associated with significantly greater increases in dentinal wall thickness (p = 0.002), root length (p = 0.010), and reductions in apical diameter (p < 0.001) over time compared with apexification. Apical closure was observed significantly more frequently in the RET group (p < 0.001). Periapical healing improved in both groups, while overall clinical outcomes appeared broadly similar. Within the limitations of this retrospective observational study, RET incorporating an additional calcium hydroxide-based step for blood clot stabilisation appears to be a clinically applicable approach for promoting root development in traumatised immature teeth. Further prospective and controlled studies are required to confirm these findings and to better define the role of this adjunctive step. Full article

(This article belongs to the Special Issue Recent Advancements in Novel Dental Materials)

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Review

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23 pages, 1296 KB

Open AccessReview

Clinical Readiness of Additively Manufactured Dental Ceramics for Crowns, Veneers, and Partial-Coverage Restorations: A Scoping Review and Evidence Map

by Andrei Vorovenci, Oana Eftene, Mihai Burlibașa, Andi Ciprian Drăguș, Mădălina Adriana Malița, Mihaela Romanița Gligor, Viorel Ștefan Perieanu, Camelia Ionescu, Ruxandra Stănescu, Elena-Cristina Marcov, Cristina Maria Șerbănescu, Mircea Popescu, Andrei Burlibașa and Iuliana Babiuc

Appl. Sci. 2026, 16(7), 3594; https://doi.org/10.3390/app16073594 - 7 Apr 2026

Cited by 1 | Viewed by 721

Abstract

This scoping review mapped the clinical readiness of directly additively manufactured (AM) dental ceramics for single-unit definitive restorations (crowns, veneers, and partial-coverage restorations) using a predefined review-specific five-tier readiness framework (R1–R5) designed to organize evidence maturity from restoration-relevant foundational studies to comparative clinical evidence. MEDLINE (PubMed), Scopus, Web of Science Core Collection, EBSCO (Dentistry and Oral Sciences Sources), and ClinicalTrials.gov were searched from inception to February 2026, with citation tracking. Thirty-five sources were included: 31 in vitro studies and 4 clinical studies. Evidence clustered in preclinical tiers, with most studies classified as restoration-level in vitro investigations (R2, 22/35) or foundational specimen-level studies explicitly linked to restorative performance (R1, 9/35); only one feasibility study reached R3 (1/35), three studies provided comparative clinical evidence (R4, 3/35), and no R5-level evidence was identified. The additively manufactured definitive restorations evaluated were zirconia-based. Most restoration-level studies addressed zirconia crowns (18/35), with fewer studies focusing on veneers/laminates (5/35) and occlusal veneers/tabletops (2/35). Across AM routes (most commonly vat photopolymerization ceramic workflows and nanoparticle jetting) outcomes focused on fit/adaptation, manufacturing accuracy, mechanical performance, and aging simulations; clinical studies reported short- to mid-term performance using standardized evaluation criteria. Overall, the evidence suggests technical feasibility and increasing restoration-level evaluation under controlled conditions, but clinical applicability remains preliminary because higher-readiness clinical evidence is still limited. Future work should prioritize standardized reporting, clinically relevant aging/fatigue paradigms, and longer-term comparative clinical studies. Full article

(This article belongs to the Special Issue Recent Advancements in Novel Dental Materials)

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Other

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19 pages, 850 KB

Open AccessSystematic Review

The Role of the Interproximal Enamel Reduction in Orthodontics: A Systematic Review

by Francesca Gazzani, Letizia Lugli, Francesca Chiara De Razza, Giuseppina Laganà, Chiara Pavoni, Paola Cozza and Roberta Lione

Appl. Sci. 2025, 15(19), 10645; https://doi.org/10.3390/app151910645 - 1 Oct 2025

Cited by 1 | Viewed by 3978

Abstract

Background: The aim of this systematic review was to critically evaluate the clinical indications, the techniques, and the effects of interproximal enamel reduction (IPR). Methods: A systematic review of the existing literature was carried out following the PRISMA guidelines in the following databases: PubMed-Medline, Scopus, Embase, Web of Science, and Cochrane. The search was conducted according to the established inclusion and exclusion criteria until March 2025. Results: A total of 420 articles were identified. Only 23 were selected for the analysis. The efficiency and validity of IPR as a non-extraction protocol adopted in several orthodontic cases was reported in all selected studies. No negative effects in terms of enamel demineralization, residual irregularities, caries incidence, and periodontal damages were reported. Using oscillating mechanical techniques was more efficient than using manual ones in terms of efficiency, predictability, and respect of enamel surfaces. Overall, the quality of the selected articles was low. More randomized controlled clinical trials with in vivo tests, research with longer follow-up times, and high-quality studies are needed to assess more valid statements. Conclusions: Higher accuracy of enamel reduction is achieved by means of oscillating mechanical techniques, which allows for more effective and predictable IPR procedures, as well as more preserved residual enamel surfaces. Full article

(This article belongs to the Special Issue Recent Advancements in Novel Dental Materials)

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