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Antioxidants
Special Issues
Bioactive Antioxidants: Structural Characterization, Synthetic Pathways, and Clinical Applications
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Bioactive Antioxidants: Structural Characterization, Synthetic Pathways, and Clinical Applications

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Extraction and Industrial Applications of Antioxidants".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 1203

Special Issue Editor

Prof. Dr. Jolanta Flieger

E-Mail Website
Guest Editor
Department of Analytical Chemistry, Medical University of Lublin, Lublin, Poland
Interests: spectroscopy; biochemistry; environmental chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The therapeutic potential of bioactive antioxidants depends critically on their structural specificity, synthetic accessibility, and demonstrated efficacy in biological systems.

Recent advances in this field focus on three key aspects—innovative synthetic strategies to design and optimize antioxidant molecules, advanced structural characterization techniques to elucidate their mechanisms of action, and the rigorous evaluation of their therapeutic potential in disease prevention and treatment.

We cordially invite researchers to submit original research articles and comprehensive reviews for this Special Issue, showcasing cutting-edge advances in bioactive antioxidant research. We welcome contributions covering various aspects, primarily focusing on the following: new synthetic or biosynthetic approaches to antioxidant production, the prediction of activity based on structure–activity relationships, state-of-the-art structural characterization methods, and mechanistic studies of therapeutic effects at the molecular and cellular level, as well as clinical and translational studies.

We look forward to receiving your contributions.

Prof. Dr. Jolanta Flieger
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive antioxidants
  • therapeutic potential
  • synthetic strategies
  • structural characterization

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Published Papers (2 papers)

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Research

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20 pages, 4060 KB  
Article
Deinoxanthin Recovers H2O2-Stimulated Oxidative Complications of Bone Marrow-Derived Cells and Protects Mice from Irradiation-Mediated Impairments
by Govinda Bhattarai, Sung-Ho Kook, Saroj Kumar Shrestha, Jeong-Hwan Park, Shankar Rijal, Gyeongho Tae, Doyoung Hwang, Seung-Moon Park, Jeong-Chae Lee and Young-Mi Jeon
Antioxidants 2025, 14(10), 1180; https://doi.org/10.3390/antiox14101180 - 26 Sep 2025
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Abstract
A growing interest is focused on the efficient production of deinoxanthin (DEIX) and its use as a bioactive antioxidant. Here, we produced DEIX from Deinococcus radiodurans and examined how DEIX regulates hydrogen peroxide (H2O2)-mediated oxidative behaviors in mouse-derived bone [...] Read more.
A growing interest is focused on the efficient production of deinoxanthin (DEIX) and its use as a bioactive antioxidant. Here, we produced DEIX from Deinococcus radiodurans and examined how DEIX regulates hydrogen peroxide (H2O2)-mediated oxidative behaviors in mouse-derived bone marrow (BM) stromal cells and BM monocytes. We also evaluated whether oral supplementation with DEIX has radioprotective potential against total body irradiation (TBI)-mediated impairments in growth, organs, survival, and hematopoietic development using a mouse model. The direct addition of DEIX recovered H2O2-mediated oxidative disorders in the proliferation and the balance between osteoblast and osteoclast activity of the BM-derived cells in a dose-dependent manner. We found that recovery was closely associated with the DEIX’s potencies to remove cellular reactive oxygen species and to restore the expression of key molecules that tightly control bone homeostasis. Long-term oral supplementation with DEIX (25 mg/kg body weight, once per day for 42 consecutive days) protected mice against sub-lethal TBI (5 Gy)-mediated decreases in organ and body weights and lifespan. Supplemental DEIX also inhibited TBI-mediated structural damage in organs and restored endogenous antioxidant defense systems in the liver of TBI-exposed mice. Moreover, supplemental DEIX recovered a dysregulated hematopoietic process in TBI-exposed mice. Collectively, our results introduce an efficient method to produce DEIX and demonstrate its potency to recover oxidative cellular complication in H2O2-exposed BM-derived cells. Overall, our findings suggest that DEIX is a great antioxidative molecule to prevent or protect TBI-mediated systemic damages. Full article
(This article belongs to the Special Issue Bioactive Antioxidants: Structural Characterization, Synthetic Pathways, and Clinical Applications)
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Review

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31 pages, 1574 KB  
Review
Nanoparticle-Based Assays for Antioxidant Capacity Determination
by Jolanta Flieger, Natalia Żuk, Ewelina Grabias-Blicharz, Piotr Puźniak and Wojciech Flieger
Antioxidants 2025, 14(12), 1506; https://doi.org/10.3390/antiox14121506 - 15 Dec 2025
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Abstract
Thanks to both endogenous and exogenous antioxidants (AOs), the antioxidant defense system ensures redox homeostasis, which is crucial for protecting the body from oxidative stress and maintaining overall health. The food industry also exploits the antioxidant properties to prevent or delay the oxidation [...] Read more.
Thanks to both endogenous and exogenous antioxidants (AOs), the antioxidant defense system ensures redox homeostasis, which is crucial for protecting the body from oxidative stress and maintaining overall health. The food industry also exploits the antioxidant properties to prevent or delay the oxidation of other molecules during processing and storage. There are many classical methods for assessing antioxidant capacity/activity, which are based on mechanisms such as hydrogen atom transfer (HAT), single electron transfer (SET), electron transfer with proton conjugation (HAT/SET mixed mode assays) or the chelation of selected transition metal ions (e.g., Fe2+ or Cu1+). The antioxidant capacity (AOxC) index value can be expressed in terms of standard AOs (e.g., Trolox or ascorbic acid) equivalents, enabling different products to be compared. However, there is currently no standardized method for measuring AOxC. Nanoparticle sensors offer a new approach to assessing antioxidant status and can be used to analyze environmental samples, plant extracts, foodstuffs, dietary supplements and clinical samples. This review summarizes the available information on nanoparticle sensors as tools for assessing antioxidant status. Particular attention has been paid to nanoparticles (with a size of less than 100 nm), including silver (AgNPs), gold (AuNPs), cerium oxide (CeONPs) and other metal oxide nanoparticles, as well as nanozymes. Nanozymes belong to an advanced class of nanomaterials that mimic natural enzymes due to their catalytic properties and constitute a novel signal transduction strategy in colorimetric and absorption sensors based on the localized surface plasmon resonance (LSPR) band. Other potential AOxC sensors include quantum dots (QDs, <10 nm), which are particularly useful for the sensitive detection of specific antioxidants (e.g., GSH, AA and baicalein) and can achieve very good limits of detection (LOD). QDs and metallic nanoparticles (MNPs) operate on different principles to evaluate AOxC. MNPs rely on optical changes resulting from LSPR, which are monitored as changes in color or absorbance during synthesis, growth or aggregation. QDs, on the other hand, primarily utilize changes in fluorescence. This review aims to demonstrate that, thanks to its simplicity, speed, small sample volumes and relatively inexpensive instrumentation, nanoparticle-based AOxC assessment is a useful alternative to classical approaches and can be tailored to the desired aim and analytes. Full article
(This article belongs to the Special Issue Bioactive Antioxidants: Structural Characterization, Synthetic Pathways, and Clinical Applications)
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