Directed Lipid Oxygenation as an Antioxidant System
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".
Deadline for manuscript submissions: 25 June 2026 | Viewed by 16
Special Issue Editor
2. Temetry Faulty of Medicine, Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada
Interests: eicosanoids; lipoxygenase; hepoxilins; analogs; marine products; inflammation; cancer; anti-platelet
Special Issue Information
Dear Colleagues,
Molecular oxygen is essential for all life through aerobic respiration. It produces energy through the generation of ATP, the energy molecule. While molecular oxygen is functionally important for all cellular processes in the body, its metabolites can be either negative (as free radicals or ROS) on one hand, or positive on the other hand, producing oxygenated products which act as biologically active substances. Although there are many enzymatic reactions and vitamins that control ROS, this Special Issue proposes to address the positive actions of peroxidation/oxygenation of lipids generating biological pathways through the LOX/COX enzyme systems. This Special Issue will primarily address the actions of new or previously (un)reported oxygenated lipid metabolites from polyunsaturated fatty acids (PUFAs) from their free form or when esterified to phospholipids (PLs) including their synthesis (chemical and biological), biological actions (pharmacology), disease (pathology), therapeutics (actual or potential), and genetics. Since peroxidation of PUFA occurs both in free form and when attached to phospholipids, approaches dealing with oxygenated PL metabolites and their release by phospholipases shall also be entertained. In essence, these oxygenated lipid metabolic pathways could be considered lipid antioxidant pathways since they deprive molecular oxygen from routing through the ROS pathway and therefore expose their own second messenger biological actions. New contributions to this Special Issue are invited in the above set of areas.
Dr. Cecil Pace-Asciak
Guest Editor
Manuscript Submission Information
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Keywords
- COX/LOX
- phospholipases
- mono, di and tri HPETES/HETES
- ROS
- antioxidants
- second messengers
- biological actions
- pathology
- therapeutics
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