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Antioxidants
Special Issues
Oxidative Stress and Arterial Blood Pressure
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Oxidative Stress and Arterial Blood Pressure

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 8931

Special Issue Editors

Dr. Isabel Hernández

E-Mail Website
Guest Editor
Physiology Department, Institute of Biomedical Research (IMIB-Arrixaca), Universidad de Murcia, 30120 Murcia, Spain
Interests: oxidative stress; inflammation; endothelial function; cardiovascular diseases
Dr. María Teresa Llinas Más

E-Mail Website
Guest Editor
Physiology Department, Institute of Biomedical Research (IMIB-Arrixaca), Universidad de Murcia, 30120 Murcia, Spain
Interests: pregnancy; hypertension; renal; oxidative stress; inflammation

Special Issue Information

Dear Colleagues,

Many studies have illustrated the role of oxidative stress in mediating hypertension associated with various pathologies, including obesity, chronic kidney disease, diabetes, and preeclampsia. Oxidative stress is defined as an imbalance between prooxidants and antioxidants, resulting in an excessive production of reactive oxygen species (ROS). ROS include superoxide anion radical, hydrogen peroxide, hydroxyl radical, peroxynitrite, and lipid radicals. Imbalanced ROS generation/elimination can cause structural and physiological damage to DNA, RNA, proteins, and lipids, thereby contributing to inflammation, endothelial dysfunction, vascular injury, and tissue damage associated with hypertension. Furthermore, high levels of ROS can reduce the bioavailability of nitric oxide, a key factor in maintaining the vascular tone.

We encourage you to contribute your latest research or review to this Special Issue, which aims to compile the latest advances in the understanding of the relationship between oxidative stress and hypertension, as well as their potential for designing and evaluating novel antihypertensive therapies. This can include studies relating to any of the following topics:  the molecular mechanisms of vascular dysfunction in essential hypertension or associated with other pathologies; oxidative stress addressed through genetic and epigenetic approaches (histone acetylation/methylation, DNA methylation, regulation of microRNA); development of new strategies such as physical training and therapeutics targeting eNOS with oxidative impairment or soluble guanylate cyclase; the delivery of antioxidants directly to the endothelium through specific ligands or through vectors.

We look forward your contribution.

Dr. Isabel Hernández
Dr. María Teresa Llinas Más
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • nitric oxide
  • hypertension
  • endothelial function
  • epigenetic

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Published Papers (2 papers)

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Research

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15 pages, 2111 KiB  
Article
The Vascular Function of Resistance Arteries Depends on NADPH Oxidase 4 and Is Exacerbated by Perivascular Adipose Tissue
by Patrick Diaba-Nuhoho, Jennifer Mittag, Coy Brunssen, Henning Morawietz and Heike Brendel
Antioxidants 2024, 13(5), 503; https://doi.org/10.3390/antiox13050503 - 23 Apr 2024
Cited by 1 | Viewed by 1066
Abstract
The NADPH oxidase NOX4 that releases H2O2 can mediate vasoprotective mechanisms under pathophysiological conditions in conductive arteries. However, the role of NOX4 in resistance arteries and in perivascular adipose tissue is not well understood. We hypothesized that NOX4 is of [...] Read more.
The NADPH oxidase NOX4 that releases H2O2 can mediate vasoprotective mechanisms under pathophysiological conditions in conductive arteries. However, the role of NOX4 in resistance arteries and in perivascular adipose tissue is not well understood. We hypothesized that NOX4 is of functional importance in resistance arteries and perivascular adipose tissue under dyslipidemia conditions. We detected elevated NOX4 expression in murine and human vessels under dyslipidemia. Diminishing Nox4 under these conditions led to endothelial dysfunction in resistance arteries. The mesenteric arteries of Nox4−/−/Ldlr−/− mice revealed decreased eNos mRNA expression. Inhibition of eNOS in those vessels did not affect vascular function, while in Ldlr−/− mice endothelial function was significantly altered. Anticontractile properties of perivascular adipose tissue at resistance arteries were diminished in Nox4−/−/Ldlr−/− compared with Ldlr−/− mice. In addition, the presence of perivascular adipose tissue further worsened endothelial dysfunction in mesenteric arteries under dyslipidemia conditions. Perivascular adipose tissue from mesenteric arteries revealed a higher expression of markers of white adipocytes compared to markers of beige/brown adipocytes. Among those white adipocyte markers, leptin was significantly less expressed in perivascular adipose tissue from Nox4−/−/Ldlr−/− mice compared with Ldlr−/− mice. Furthermore, in human perivascular adipose tissue with a profound pattern of white adipocyte marker genes, we detected a correlation of NOX4 and LEP expression. In addition, incubating arterial vessels with leptin induced nitrite release, indicating increased eNOS activity. In humans, a higher expression of leptin in perivascular adipose tissue correlated with eNOS expression in the corresponding left internal mammary artery. In conclusion, vascular function of resistance arteries was dependent on Nox4-derived H2O2, especially under dyslipidemia conditions. Perivascular adipose tissue of the mesenteric arteries with white adipose tissue characteristics further aggravated endothelial function through reduced leptin-eNOS signaling. Full article
(This article belongs to the Special Issue Oxidative Stress and Arterial Blood Pressure)
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Review

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22 pages, 1874 KiB  
Review
Oxidative Stress, Antioxidants and Hypertension
by Michael Amponsah-Offeh, Patrick Diaba-Nuhoho, Stephan Speier and Henning Morawietz
Antioxidants 2023, 12(2), 281; https://doi.org/10.3390/antiox12020281 - 27 Jan 2023
Cited by 39 | Viewed by 6638
Abstract
As a major cause of morbidity and mortality globally, hypertension remains a serious threat to global public health. Despite the availability of many antihypertensive medications, several hypertensive individuals are resistant to standard treatments, and are unable to control their blood pressure. Regulation of [...] Read more.
As a major cause of morbidity and mortality globally, hypertension remains a serious threat to global public health. Despite the availability of many antihypertensive medications, several hypertensive individuals are resistant to standard treatments, and are unable to control their blood pressure. Regulation of the renin-angiotensin-aldosterone system (RAAS) controlling blood pressure, activation of the immune system triggering inflammation and production of reactive oxygen species, leading to oxidative stress and redox-sensitive signaling, have been implicated in the pathogenesis of hypertension. Thus, besides standard antihypertensive medications, which lower arterial pressure, antioxidant medications were tested to improve antihypertensive treatment. We review and discuss the role of oxidative stress in the pathophysiology of hypertension and the potential use of antioxidants in the management of hypertension and its associated organ damage. Full article
(This article belongs to the Special Issue Oxidative Stress and Arterial Blood Pressure)
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