Oxidative Stress and Precision Medicine in Cardiometabolic and Cardiovascular Disease: Mechanisms, Biomarkers, and Therapeutic Targets
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 43
Special Issue Editors
Interests: biomarker discovery; quantitiative liquid chromatography–mass spectrometry; cardiovascular disease; chronic diseases; oxidative stress
Interests: biomarker discovery; liquid chromatography-mass spectrometry; nanoparticles; cardiovascular disease; biostatistics; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to announce the new edition of our Special Issue “Oxidative Stress and Precision Medicine in Cardiometabolic and Cardiovascular Disease: Mechanisms, Biomarkers, and Therapeutic Targets”.
Cardiometabolic and cardiovascular diseases, including atherosclerosis, diabetes, obesity, hypertension, and heart failure, remain major global causes of morbidity and mortality. Increasing evidence indicates that oxidative stress, mitochondrial dysfunction, and disrupted redox signaling are fundamental drivers of vascular injury, metabolic dysregulation, and inflammation. These processes promote endothelial dysfunction, lipid peroxidation, and apoptotic injury, contributing to both metabolic and cardiovascular pathologies. Despite decades of research, translating antioxidants from redox science into clinical applications remains limited, underscoring the urgent need for mechanistic insight and precision biomarker discovery.
This Special Issue of Antioxidants focuses on oxidative stress, redox omics, and precision cardiometabolic medicine. We invite original research and reviews that cover the following:
- Explore molecular and cellular mechanisms linking oxidative and nitrosative stress to cardiometabolic dysfunction.
- Identify or validate novel redox biomarkers through mass spectrometry, metabolomics, lipidomics, or proteomics.
- Investigate therapeutic targets or redox modulating interventions for cardiometabolic and cardiovascular diseases.
Submissions employing artificial intelligence (AI), machine learning, or systems biology to advance biomarker discovery, predictive modelling, and personalized therapeutic strategies are particularly encouraged. Translational and clinical studies evaluating antioxidant therapies, redox modulators, or dietary/pharmacological approaches are also highly relevant.
By integrating mechanistic redox biology, precision diagnostics, and computational analytics, this Special issue aims to accelerate the development of AI-enabled, biomarker-driven antioxidant therapies and advance precision medicine for cardiometabolic and cardiovascular health.
We warmly invite your valuable contributions to this Special Issue.
Dr. Leroy Sivappiragasam Pakkiri
Dr. Chester Lee Drum
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxidative stress
- precision medicine
- cardiometabolic disease
- cardiovascular disease
- redox signaling
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