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Antioxidants
Special Issues
Oxidative Stress and Redox Signaling in Cancer Progression and Therapy
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Oxidative Stress and Redox Signaling in Cancer Progression and Therapy

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 May 2025 | Viewed by 5019

Special Issue Editors

Prof. Dr. Kui Wang

E-Mail Website
Guest Editor
West China School of Basic Medical Sciences & Forensic Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
Interests: cancer biology; oxidative stress; ROS; cancer metabolism
Prof. Dr. Yunlong Lei

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China
Interests: cancer; autophagy; ROS; transcription factors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Compared to their normal counterparts, cancer cells often exhibit higher levels of intracellular reactive oxygen species (ROS), the byproducts of metabolic processes. It is well known that the excessive accumulation of ROS plays a cytotoxic role by causing oxidative damage to biomolecules and organelles. In order to cope with ROS-induced oxidative stress, cancer cells employ powerful enzymatic and non-enzymatic antioxidant systems to ensure that ROS levels are maintained below the detrimental threshold. In addition, the oxidative damage of biomolecules and organelles can be repaired or removed by various mechanisms, including autophagy, proteasomal degradation, and the DNA damage response. This cancer-specific redox homeostasis supports cancer progression by promoting cell survival, growth, metastasis, and therapeutic resistance. Specifically, ROS below the detrimental threshold levels can act as signaling molecules to manipulate redox signaling by directly (oxidative post-translational modifications, termed oxPTMs) or indirectly (other PTMs) affecting protein functions, thereby participating in the regulation of various biological events in cancer.

Given the cytotoxic roles of ROS, a variety of strategies promoting ROS accumulation above the detrimental threshold have been extensively explored for cancer treatment. Nevertheless, a variety of synthetic or natural antioxidants that disturb global redox signaling have also been investigated for their potential utilization in cancer prevention and therapy. In this Special Issue of Antioxidants, original research or review articles that discuss oxidative stress and redox signaling in cancer progression and therapy are welcome.

Prof. Dr. Kui Wang
Prof. Dr. Yunlong Lei
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ROS
  • oxidative stress
  • redox signaling
  • cancer
  • antioxidants

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Published Papers (3 papers)

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Review

20 pages, 3541 KiB  
Review
Oxidative Stress and Redox Signaling in Gastric Cancer: From Mechanisms to Therapeutic Implications
by Zehua Chen, Jiawu Fan, Xiaolong Chen, Kun Yang and Kui Wang
Antioxidants 2025, 14(3), 258; https://doi.org/10.3390/antiox14030258 - 24 Feb 2025
Viewed by 764
Abstract
Oxidative stress, which is characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, has critical roles in the initiation, progression, and treatment of gastric cancer. On the one hand, an excessive ROS accumulation induces oxidative damage and cancer cell [...] Read more.
Oxidative stress, which is characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, has critical roles in the initiation, progression, and treatment of gastric cancer. On the one hand, an excessive ROS accumulation induces oxidative damage and cancer cell death. On the other hand, moderate levels of ROS cause genetic mutations and dysregulation of signaling pathways to promote proliferation, inflammation, angiogenesis, and metastasis in gastric cancer. Notably, emerging evidence has revealed that ROS also mediate oxidative post-translational modifications (oxPTMs) of redox-sensitive proteins, which can directly affect protein functions and regulate redox signaling in cancer cells. Therefore, elucidating the regulatory mechanisms of oxidative stress and redox signaling in gastric cancer holds great promise to identify novel therapeutic targets or redox-targeting strategies. This review will summarize the mechanisms of oxidative stress in regulating the hallmarks of gastric cancer and highlight the roles of ROS-mediated oxPTMs in gastric cancer. In addition, we will discuss emerging strategies targeting oxidative stress for the treatment of gastric cancer, with an emphasis on the use of bioactive natural products and nanomaterials. Full article
(This article belongs to the Special Issue Oxidative Stress and Redox Signaling in Cancer Progression and Therapy)
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33 pages, 1923 KiB  
Review
Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers
by Siqi Li, Hang Yuan, Liang Li, Qin Li, Ping Lin and Kai Li
Antioxidants 2025, 14(2), 201; https://doi.org/10.3390/antiox14020201 - 10 Feb 2025
Cited by 2 | Viewed by 1651
Abstract
Oxidative stress is a common event involved in cancer pathophysiology, frequently accompanied by unique lipid metabolic reprogramming phenomena. Oxidative stress is caused mainly by an imbalance between the production of reactive oxygen species (ROS) and the antioxidant system in cancer cells. Emerging evidence [...] Read more.
Oxidative stress is a common event involved in cancer pathophysiology, frequently accompanied by unique lipid metabolic reprogramming phenomena. Oxidative stress is caused mainly by an imbalance between the production of reactive oxygen species (ROS) and the antioxidant system in cancer cells. Emerging evidence has reported that oxidative stress regulates the expression and activity of lipid metabolism-related enzymes, leading to the alteration of cellular lipid metabolism; this involves a significant increase in fatty acid synthesis and a shift in the way in which lipids are taken up and utilized. The dysregulation of lipid metabolism provides abundant intermediates to synthesize biological macromolecules for the rapid proliferation of cancer cells; moreover, it contributes to the maintenance of intracellular redox homeostasis by producing a variety of reducing agents. Moreover, lipid derivatives and metabolites play critical roles in signal transduction within cancer cells and in the tumor microenvironment that evades immune destruction and facilitates tumor invasion and metastasis. These findings suggest a close relationship between oxidative stress and lipid metabolism during the malignant progression of cancers. This review focuses on the crosstalk between the redox system and lipid metabolic reprogramming, which provides an in-depth insight into the modulation of ROS on lipid metabolic reprogramming in cancers and discusses potential strategies for targeting lipid metabolism for cancer therapy. Full article
(This article belongs to the Special Issue Oxidative Stress and Redox Signaling in Cancer Progression and Therapy)
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27 pages, 2157 KiB  
Review
Role of Oxidative Stress in the Occurrence, Development, and Treatment of Breast Cancer
by Rui Dong, Jing Wang, Ruiqi Guan, Jianwei Sun, Ping Jin and Junling Shen
Antioxidants 2025, 14(1), 104; https://doi.org/10.3390/antiox14010104 - 17 Jan 2025
Cited by 1 | Viewed by 1750
Abstract
Breast cancer is one of the most prevalent cancers worldwide. Recent studies have increasingly emphasized the role of oxidative stress in the initiation and progression of breast cancer. This article reviews how oxidative stress imbalance influences the occurrence and advancement of breast cancer, [...] Read more.
Breast cancer is one of the most prevalent cancers worldwide. Recent studies have increasingly emphasized the role of oxidative stress in the initiation and progression of breast cancer. This article reviews how oxidative stress imbalance influences the occurrence and advancement of breast cancer, elucidating the intricate mechanisms through which reactive oxygen species (ROS) operate in this context and their potential therapeutic applications. By highlighting these critical insights, this review aims to enhance our understanding of oxidative stress as a potential target for innovative therapeutic strategies in the management of breast cancer. Full article
(This article belongs to the Special Issue Oxidative Stress and Redox Signaling in Cancer Progression and Therapy)
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