Antioxidants in Prevention and Treatment of Diabetes
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 15
Special Issue Editors
Interests: metabolic mechanisms of diabetes; type 2 diabetes; antioxidant activity
Special Issue Information
Dear Colleagues,
The global diabetes pandemic continues to represent a burden on healthcare systems due to its associated microvascular complications and increased cardiovascular mortality. Significant results have emerged from cardiovascular outcome trials (CVOTs) for newer anti-diabetic agents (SGLT2 inhibitors and GLP-1 receptor agonists), which have demonstrated benefits beyond glucose control by reducing vascular events. This effect is being increasingly linked to a reduction in oxidative stress, and there is significant experimental evidence that oxidative stress plays a major role in diabetes and its complications.
However, clinical trials of direct antioxidant therapies have yielded conflicting results regarding the prevention of vascular disease, despite showing promise in specific patient sub-groups. The COVID-19 pandemic has further highlighted the vulnerability of individuals with type 2 diabetes, particularly those with insulin resistance or overweight or from deprived backgrounds. A new hypothesis suggests that severe disease in these groups may be connected to dysregulated antioxidant defenses. Consequently, a key future research aim is to achieve the targeted modulation of the body's antioxidant pathways to develop new treatments for diabetic vasculopathy.
Dr. Karima Zitouni
Dr. Kenneth Earle
Guest Editors
Manuscript Submission Information
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Keywords
- diabetic vasculopathy
- oxidative stress
- type 2 diabetes
- antioxidant defenses
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