Antioxidant Role of High-Density Lipoprotein—2nd Edition
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 629
Editor
Interests: atherosclerosis; diabetes mellitus; dyslipidaemia; insulin resistance; lipids; lipoproteins
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
There is accumulating evidence that high-density lipoprotein (HDL) can protect low-density lipoproteins (LDL) and cell membranes against oxidative modification, which can contribute to numerous disease processes. The most studied disease has been atheroma, but diabetic complications, sepsis, resistance to infection, neoplasms, inflammation and other conditions have all been linked to a loss of protection against oxidation associated with HDL. Although the role of HDL in lipid metabolism is well elucidated, its role as the dominant lipoprotein in tissue fluid—which bathes nearly every cell in the body—is often overlooked. HDL is a repository of numerous proteins and lipids that can potentially protect both tissues and lipoproteins against oxidative damage.
In diabetes, metabolic syndrome, and inflammation, HDL undergoes compositional changes, leading to decreased antioxidant activity. This correlates with its decreased capacity to protect against oxygen free radicals and lactone attack on proteins and phospholipids, posing regulatory and functional consequences.
Our views about HDL have undergone radical revision in recent years: evidence remains largely lacking that it critical for reverse cholesterol transport: most excess cholesterol secreted by the liver is removed before cellular uptake by a process in which HDL is not rate-limiting.
It has been widely reported that dysfunctional HDL—for example, deficient in paraoxonase, apolipoprotein AI, and antioxidant activity—alongside increased serum amyloid A and apolipoprotein AII content may be the true culprit of atheroma pathogenesis and probably other diseases. Serum HDL cholesterol measurement is often an inadequate surrogate for the direct detection of this dysfunctional HDL.
This series of contributions will highlight the mechanisms and components contributing to the antioxidant role of HDL and its disease associations.
Prof. Dr. Paul Durrington
Guest Editor
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Keywords
- lipoprotein oxidation
- cell membrane oxidation
- HDL antioxidant activity
- glycosylation
- atherosclerosis
- paraoxonase
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Related Special Issue
- Antioxidant Role of High-Density Lipoprotein in Antioxidants (9 articles)
