Role of Natural Antioxidant Compounds in Slowing Neurodegeneration
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 43
Special Issue Editor
Interests: plant extract; polyphenols; neurodegeneration; human health; microbiota
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegeneration is a pathological process causing progressive neuronal damage, potentially leading to cell death. Neurodegenerative diseases share a common feature: neurodegeneration, leading to functional, cognitive, and motor impairments. There are many causes responsible for neurodegeneration, including oxidative stress, misfolded proteins, neuroinflammation, mitochondrial dysfunction, brain injury, autophagy, and gene mutations. Among these, oxidative stress and inflammation appear to be a common denominator of neurodegeneration. Currently, no drug is known to cure neurodegenerative diseases definitively. Some lifestyles may help reduce the development of these diseases; for example, a balanced diet is associated with a lower risk of some neurodegenerative conditions. A diet focusing on fruits, vegetables, monounsaturated fats, fish, whole grains, legumes, and nuts, with moderate alcohol intake and limited red meat, dairy, saturated fats, and refined cereals, may help protect the brain.
Phytochemicals, bioactive compounds in plants, show promising therapeutic potential for many human diseases by possibly preventing or treating various pathological aspects. These substances often exhibit antioxidant and anti-inflammatory effects in the brain, activating protective mechanisms.
This Special Issue is aimed at the following:
- Researchers dealing with neurodegeneration and the development of natural compounds capable of slowing its progression;
- Botanists describing an extract with protective properties for the brain;
- Neurologists who study the onset of neurodegenerative diseases and can propose non-pharmacological strategies to address them;
- Researchers studying microbiota and the close gut–brain connection;
- All scholars passionate about this topic.
Dr. Jessica Maiuolo
Guest Editor
Manuscript Submission Information
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Keywords
- neurodegeneration
- neurodegenerative diseases
- plant extracts
- natural compounds
- phytochemicals
- polyphenols
- gut-microbiota
- gut–brain axis
- brain and short-chain fatty acids
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