Antioxidants and Their Role in Kidney Machine Perfusion and Kidney Injury—2nd Edition

Dear Colleagues,

In light of the great response we received to our previous Special Issue, "Antioxidants and Their Role in Kidney Machine Perfusion and Kidney Injury", we decided to revisit this topic.

Localized and systemic ischemia reperfusion injury (IRI) remain clinically relevant issues. Following the heart and the brain, the kidney is the most vulnerable organ to IRI due to the high oxygen consumption of tubular transport processes. The regeneration mechanisms initiated through the onset of tubular damage caused by IRI often lead to irreversible interstitial fibrosis and, potentially, to the development of chronic kidney disease. Kidney transplantation procedures represent the ultimate scenario of ischemia and reperfusion, consisting of many steps that all contribute to organ damage through IRI:

1. Organ retrieval with a varying ischemia time, especially in donation after cardiac death;
2. Cold storage (CS) or varying machine perfusion (MP) strategies for organ transport;
3. Time until the onset of reperfusion during implantation.

All these steps are crucial factors in the formation of reactive oxygen species (ROSs), which are a major cause of organ damage throughout the process of IRI. Applying antioxidants represents a promising strategy to prevent or limit ROS formation. Some of the recent topics in this field include the supplementation of organ perfusates with antioxidative vitamins or enzymes to catalyze processes with antioxidative potential, as well as the direct targeting of mitochondrial-triggered ROS formation. In particular, machine perfusion (MP) in cold, sub-normothermic, or normothermic settings is becoming the key focus of clinical transplant centers around the world, to improve donor-organ quality. The combination of an optimized perfusion strategy and optimized perfusate will be the key in future to overcome the global organ shortage.

This Special Issue aims to collect papers that focus on the improvement of whole-kidney machine perfusion and kidney injury by applying antioxidant-based strategies.

Dr. Christian Bleilevens
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• machine perfusion
• kidney graft preservation
• ex vivo kidney perfusion
• in vitro kidney perfusion
• antioxidants
• kidney transplantation