Hormonal and Redox Regulation in Cancer, Metabolic Dysfunction, and Neurodegenerative Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 20 June 2026 | Viewed by 980
Special Issue Editor
Interests: cancer; redox; endocrinology; herbal medicine; pathology; cancer stem cell; cancer reprogramming; miRNA; alternative splicing factor; drug resistance; drug development; drug delivery system
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hormonal signaling and redox homeostasis form an essential regulatory axis in cancer, metabolic dysfunction, and neurodegenerative diseases. Hormones such as melatonin, estrogen, insulin, and glucocorticoids act not only as systemic messengers but also as intracellular antioxidants and transcriptional modulators, shaping cellular decisions involving survival, apoptosis, and differentiation.
These molecules influence oxidative stress, mitochondrial integrity, and epigenetic reprogramming through pathways such as Nrf2/Keap1, PI3K/AKT/mTOR, AMPK/SIRT1, and NF-κB, ultimately regulating inflammation, metabolic rewriting, ferroptosis, and immune response. Moreover, redox-sensitive regulation of noncoding RNAs (miRNA, IncRNA) provides an additional epigenetic layer linking endocrine activity to oxidative adaption.
This Special issue invites multidisciplinary research exploring the molecular, pharmacological, redox-biological, and translational roles of hormones in human disease. Submissions may include experimental studies, clinical–translational research, or computational modeling. Mechanistic insights, omics-driven discoveries, natural-product-based therapeutics, redox-targeting strategies, and biomarker development are especially encouraged.
Topics of interest (include but not limited to)
- Hormonal control of redox signaling in cancer, metabolic disorders, and neurodegeneration;
- Melatonin as a redox modulator: mitochondrial regulation and epigenetic remodeling;
- Crosstalk between insulin/IGF and ROS in metabolic reprogramming;
- Redox-dependent regulation of apoptosis, autophagy, and ferroptosis in endocrine-related diseases;
- Circadian rhythm, endocrine fluctuations, and oxidative homeostasis;
- Translational and pharmacological strategies targeting hormone–redox interactions;
- Computational and pharmacoinformatic modeling of hormone-associated redox modulators;
- Synergistic actions of natural compounds with hormonal pathways in oxidative-stress-related disorders.
Dr. Moon Nyeo Park
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
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Keywords
- hormonal regulation
- redox signaling
- antioxidant hormones
- melatonin
- oxidative stress
- mitochondria
- epigenetics
- noncoding RNA
- metabolic reprogramming
- ferroptosis
- inflammation
- SIRT1/AMPK
- Nrf2/Keap1
- redox therapeutics
- translational pharmacology
- natural compounds
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