Oxidative Stress, Mitochondrial Dysfunction, and Inflammation in Autism
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 66
Special Issue Editor
Interests: oxidative stress; mitochondrial dysfunction; cellular signaling in autism and Alzheimer’s disease (AD); regulation of amyloid beta-protein fibrillization in AD; the beneficial effects of a diet with walnuts; the impact of environmental risk factors (such as bisphenol A, methylmercury, and alcohol) on development and behavioral abnormalities
Special Issue Information
Dear Colleagues,
Autism or autism spectrum disorder (ASD) is a neurodevelopmental disorder, characterized by impairments in social interaction, speech, and nonverbal communication, as well as repetitive behavior. Furthermore, gastrointestinal disturbances, sleep problems, seizures, and anxiety are also commonly co-occurring conditions in some individuals with autism. According to the U.S. Centers for Disease Control (CDC), 1 in 31 children is diagnosed with autism. Although the exact cause of autism is unknown, several studies suggest that oxidative stress, mitochondrial dysfunction, immune abnormalities, inflammation, and genetic and environmental factors are involved in the pathophysiology and development of autism. Accumulating evidence suggests that oxidative stress and mitochondrial dysfunction may provide a link between susceptibility genes and pre- and post-natal environmental risk factors in autism. Oxidative stress occurs when the levels of free radicals, i.e. reactive oxygen species (ROS) exceed the antioxidant capacity of a cell. ROS are highly toxic and oxidize vital cellular components such as lipids, proteins, and DNA, thus causing cellular damage. ROS are generated endogenously during oxidative metabolism and energy production by mitochondria and are neutralized by antioxidant defense mechanisms. Many studies have also implicated oxidative stress as a major upstream component in the signaling cascade involved in activation of redox-sensitive transcription factors and pro-inflammatory gene expression leading to an inflammatory response.
I invite you to submit original research reports and reviews to this Special Issue on autism in Antioxidants.
I look forward to your submissions.
Dr. Abha Chauhan
Guest Editor
Manuscript Submission Information
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Keywords
- autism
- oxidative stress
- mitochondria
- inflammation
- redox signaling
- antioxidants
- reactive oxygen species
- immune response
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