Melanoma and Redox Dynamics: A Crucial Tug-of-War in Tumor Onset and in Therapy Response
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 May 2026
Special Issue Editors
Interests: neuroblastoma; MYC amplification; cancer stemness; drug resistance; protein kinase C; oxidative stress; lipoperoxidation; apoptosis
Special Issues, Collections and Topics in MDPI journals
Interests: chemoresistance; cancer cell metabolism; stress adaptative cell response; cell death; redox homeostasis; redox signalling; antioxidants; glutathione
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cutaneous melanoma is among the best-known tumors induced by overproduction of Reactive Oxygen Species (ROS). Oxidative stress and redox homeostasis are involved in the onset of melanoma and its therapy resistance: oxidants promote cancer initiation and also counteract tumor spread, while antioxidants are involved in metastatization. In addition, melanoma adapt to oxidative conditions through the reprogramming of metabolism and the activation of antioxidant defenses and progressively acquires malignancy and metastatic potential.
Therefore, given the incidence and development of therapy resistance, identifying new melanoma "redox vulnerabilities" that could become effective therapeutic targets is a pressing priority. To achieve this goal, we must broaden our perspective and consider all the "competitors" participating in this "redox game". In particular, it is necessary to consider the intricate network of interactions between ROS, redox-modulated signaling pathways, redox-related transcription factors, mitochondria, cell response, as well as to understand the complexity of metabolic reprogramming and redox adaptive mechanisms.
From a therapeutic point of view, antioxidants have been found to be useful as chemopreventive agents, while oxidants may function as chemotherapeutics. Furthermore, natural compounds may act as adjuvants capable of reducing the side effects of conventional therapies, overcoming therapy resistance, and improving the survival rate of melanoma patients.
Based on these considerations, this Special Issue is dedicated to original articles and reviews focused on identifying novel redox sensitive targets to counteract melanoma progression and therapeutic resistance. Furthermore, contributions dealing with innovative experimental methods aimed at better understanding melanoma biology, as well as precision medicine approaches employing the combination of the conventional therapy with a redox-centered targeted therapy, are welcome.
Prof. Dr. Cinzia Domenicotti
Dr. Barbara Marengo
Guest Editors
Manuscript Submission Information
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Keywords
- melanoma
- redox homeostasis
- ROS
- antioxidants
- therapy resistance
- cancer metabolism
- mitochondria
- epigenetic changes
- innovative therapeutic and experimental approaches
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