Bispecific Antibodies for Dual Targeting Strategies
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (28 February 2013) | Viewed by 87078
Special Issue Editor
Special Issue Information
Dear Colleagues,
Bispecific antibodies are emerging as novel approach for dual targeting strategies combining two different antigen-binding sites within one molecules. Bispecific antibodies allow to improve binding, selectivity and efficacy, e.g. by simultaneously inhibiting two receptors or cytokines. A multitude of bispecific antibody formats have been developed in the recent years and novel applications have been established, including the dual retargeting of toxins, cytokines and growth factors with bispecific antibody fusion proteins but also dual retargeting of effector cells of the immune system with trispecific antibodies. Furthermore, dual targeting is applied to nanoparticles for delivery of drugs to target cells. Main indications include tumor therapy and the treatment of inflammatory diseases, but new areas for application of dual targeting strategies are also emerging, e.g. in diagnosis and imaging. Recent studies have already shown that bispecific antibodies show similar or even improved efficacy compared with combination therapy with two antibodies, thus offer an alternative to the parallel development, production and approval of two monoclonal antibodies.
This special issue of Antibodies addresses the growing interest in dual targeting strategies using bispecific antibodies and I kindly invite you to submit your novel results to this special issue. Welcome are manuscripts describing the application of bispecific antibodies for dual targeting strategies using in vitro and in vivo studies as well as manuscript dealing with novel bispecific antibody formats and fusion proteins suitable for dual targeting strategies.
Prof. Dr. Roland E. Kontermann
Guest Editor
Manuscript Submission Information
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Keywords
- bispecific antibodies for dual targeting of tumor cells
- bispecific antibodies for dual neutralization of cytokines and growth factors
- bispecific antibodies for dual targeting for receptor activation
- bispecific antibodies for dual retargeting of cytokines and growth factors
- bispecific antibodies for dual retargeting of immune effector cells
- bispecific antibodies for dual retargeting of toxins
- antibodies for dual retargeting of nanoparticles and liposomes
- new bispecific antibody formats
- bispecific antibodies for tumor therapy
- bispecific antibodies for therapy of inflammatory diseases
- bispecific antibodies for therapy of infectious diseases
- bispecific antibodies for imaging and diagnosis
- bispecific antibodies for half-life extension
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