Molecular Mechanisms of Stress-Mediated Bacterial Death

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 4662

Special Issue Editor


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Guest Editor
Public Health Research Institute and Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, USA
Interests: antibiotic action and resistance; bacterial cell death; flioroquinolones; gyrase; topoisomerase; reactive oxygen species

Special Issue Information

Dear Colleagues,

Death is a central feature of microbial biology. Understanding and controlling microbial death are keys to antimicrobial effectiveness, limiting tolerance and persistence, and protecting gut microbiota during antimicrobial treatment. They are also important for the industrial production of toxic compounds by microbes. Lethal stressors have recently gained attention because of the possibility that they kill bacteria through a common mechanism, even though the classes differ with respect to primary targets.

This special issue of Antibiotics will focus on novel observations concerning a variety of topics related to stress-induced death. Suitable subjects include antimicrobial tolerance and persistence, the roles of metabolic changes and signaling pathways, the accumulation of reactive oxygen and nitrogen species, death during differentiation, and programmed cell death.

We invite the submission of both primary research reports and reviews of recent literature. All articles will be peer-reviewed.

Dr. Karl Drlica
Prof. Dr. Yuzhi Hong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

27 pages, 1677 KiB  
Review
Insights into Emergence of Antibiotic Resistance in Acid-Adapted Enterohaemorrhagic Escherichia coli
by Salma Waheed Sheikh, Ahmad Ali, Asma Ahsan, Sidra Shakoor, Fei Shang and Ting Xue
Antibiotics 2021, 10(5), 522; https://doi.org/10.3390/antibiotics10050522 - 2 May 2021
Cited by 11 | Viewed by 4030
Abstract
The emergence of multidrug-resistant pathogens presents a global challenge for treating and preventing disease spread through zoonotic transmission. The water and foodborne Enterohaemorrhagic Escherichia coli (EHEC) are capable of causing intestinal and systemic diseases. The root cause of the emergence of these strains [...] Read more.
The emergence of multidrug-resistant pathogens presents a global challenge for treating and preventing disease spread through zoonotic transmission. The water and foodborne Enterohaemorrhagic Escherichia coli (EHEC) are capable of causing intestinal and systemic diseases. The root cause of the emergence of these strains is their metabolic adaptation to environmental stressors, especially acidic pH. Acid treatment is desired to kill pathogens, but the protective mechanisms employed by EHECs cross-protect against antimicrobial peptides and thus facilitate opportunities for survival and pathogenesis. In this review, we have discussed the correlation between acid tolerance and antibiotic resistance, highlighting the identification of novel targets for potential production of antimicrobial therapeutics. We have also summarized the molecular mechanisms used by acid-adapted EHECs, such as the two-component response systems mediating structural modifications, competitive inhibition, and efflux activation that facilitate cross-protection against antimicrobial compounds. Moving beyond the descriptive studies, this review highlights low pH stress as an emerging player in the development of cross-protection against antimicrobial agents. We have also described potential gene targets for innovative therapeutic approaches to overcome the risk of multidrug-resistant diseases in healthcare and industry. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Stress-Mediated Bacterial Death)
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