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Antibiotics
Special Issues
The Molecular Mechanisms of Antibiotic Resistance
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The Molecular Mechanisms of Antibiotic Resistance

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 5345

Special Issue Editors

Prof. Dr. Bo Peng

E-Mail Website
Guest Editor
School of Life and Science, Sun Yat-Sen University, Guangzhou, China
Interests: antibiotic resistance; elucidation of the metabolic features antibiotic-resistant bacteria
Prof. Dr. Xiangmin Lin

E-Mail Website
Guest Editor
1. Fujian Provincial Key Laboratory of Agroecological Processing and Safety Monitoring, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 35002, China
2. Key Laboratory of Crop Ecology and Molecular Physiology (Fujian Agriculture and Forestry University) Fujian Province University, Fuzhou 35002, China
Interests: molecular docking; antibiotics; antibiotics resistance

Special Issue Information

Dear Colleagues,

Bacterial antibiotic resistance has become a serious public health and environmental problem, beginning with the use of antibiotics over 90 years ago. It is extraordinarily necessary to understand intrinsic antibiotic resistance mechanisms for the development of new antibiotics or strategies in the future. Currently, several typical resistance mechanisms against antibiotics are known, such as reducing cellular membrane permeability or increasing efflux pumps in the bacterial membrane, altering or modifying the structure of attacking proteins, bypassing the inhibited key pathways, and introducing an exogenous plasmid carrying antibiotic resistance genes. However, since intracellular molecular mechanisms are complicated, such as molecular regulation by transcriptional factors, metabolic rearrangement and post-translational modifications (PTMs) in antibiotic resistance, and the diverse adaptation mechanisms within complex changing external environments, there is still a long way to go to reach our goals.

Due to the current poor understanding of bacterial antibiotic resistance, this Special Issue is focused on reports related to the current situation of worldwide bacterial antibiotic resistance mechanisms. We welcome and accept articles exploring antibiotic resistance mechanisms caused by efflux pumps, transferred plasmids, transcriptional factors, antimicrobial resistance genes, PTMs, etc. Furthermore, we also encourage content that provides alternative novel strategies to control or kill antibiotic-resistant bacteria besides the traditional use of antibiotics.

Dr. Bo Peng
Prof. Dr. Xiangmin Lin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bacterial antibiotics resistance
  • molecular mechanism
  • antimicrobial resistance gene
  • antimicrobial strategy
  • omics

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Published Papers (2 papers)

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Research

12 pages, 1633 KiB  
Article
Synergistic Effect of Quercetin on Antibacterial Activity of Florfenicol Against Aeromonas hydrophila In Vitro and In Vivo
by Xianliang Zhao, Xiuying Cui, Yunpeng Yang, Lei Zhu, Li Li and Xianghui Kong
Antibiotics 2022, 11(7), 929; https://doi.org/10.3390/antibiotics11070929 - 10 Jul 2022
Cited by 6 | Viewed by 2684
Abstract
The overuse or abuse of antimicrobial drugs in aquaculture, aggravates the generation of drug-resistant bacteria, which has caused potential risks to human health and the aquaculture industry. Flavonoid–antibiotic combinations have been shown to suppress the emergence of resistance in bacteria, and sometimes even [...] Read more.
The overuse or abuse of antimicrobial drugs in aquaculture, aggravates the generation of drug-resistant bacteria, which has caused potential risks to human health and the aquaculture industry. Flavonoid–antibiotic combinations have been shown to suppress the emergence of resistance in bacteria, and sometimes even reverse it. Here, the antibacterial activity of florfenicol in combination with quercetin, a potential drug to reverse multidrug resistance, was tested against Aeromonas hydrophila (A. hydrophila). Of eleven selected antimicrobial agents, quercetin and florfenicol showed the strongest bactericidal effect, and fractional inhibitory concentration (FIC) indices were 0.28, showing a highly synergistic effect. Then, the antibacterial activities of quercetin and florfenicol against A. hydrophila were further tested in vitro and in vivo. Bacterial viability of A. hydrophila decreased in a florfenicol dose-dependent manner, about 16.3–191.4-fold lower in the presence of 15 μg/mL quercetin and 0.156 to 1.25 μg/mL florfenicol than in the absence of quercetin, respectively. The cell killing was maximum at 45 μg/mL quercetin in the dose range tested plus 0.156 μg/mL florfenicol. The viability decreased over time during the combined treatment with quercetin and florfenicol by 60.5- and 115-fold in 0.156 μg/mL florfenicol and 0.625 μg/mL florfenicol, respectively. Additionally, the synergistic effect was confirmed by the bacterial growth curve. Furthermore, quercetin and florfenicol had an obvious synergistic activity in vivo, reducing the bacterial load in the liver, spleen and kidney tissues of Cyprinus carpio up to 610.6-fold compared with the florfenicol group, and improving the survival rate of infected fish from 10% in the control group to 90% in drug combinations group. These findings indicated that quercetin could potentiate the antibacterial activity of florfenicol against A. hydrophila infection and may reduce the use of antimicrobial drugs and improve the prevention and control capability of bacterial resistance. Full article
(This article belongs to the Special Issue The Molecular Mechanisms of Antibiotic Resistance)
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14 pages, 2451 KiB  
Article
Acetylome and Succinylome Profiling of Edwardsiella tarda Reveals Key Roles of Both Lysine Acylations in Bacterial Antibiotic Resistance
by Yuying Fu, Lishan Zhang, Huanhuan Song, Junyan Liao, Li Lin, Wenjia Jiang, Xiaoyun Wu and Guibin Wang
Antibiotics 2022, 11(7), 841; https://doi.org/10.3390/antibiotics11070841 - 23 Jun 2022
Cited by 4 | Viewed by 1924
Abstract
The antibiotic resistance of Edwardsiella tarda is becoming increasingly prevalent, and thus novel antimicrobial strategies are being sought. Lysine acylation has been demonstrated to play an important role in bacterial physiological functions, while its role in bacterial antibiotic resistance remains largely unclear. In [...] Read more.
The antibiotic resistance of Edwardsiella tarda is becoming increasingly prevalent, and thus novel antimicrobial strategies are being sought. Lysine acylation has been demonstrated to play an important role in bacterial physiological functions, while its role in bacterial antibiotic resistance remains largely unclear. In this study, we investigated the lysine acetylation and succinylation profiles of E. tarda strain EIB202 using affinity antibody purification combined with LC-MS/MS. A total of 1511 lysine-acetylation sites were identified on 589 proteins, and 2346 lysine-succinylation sites were further identified on 692 proteins of this pathogen. Further bioinformatic analysis showed that both post-translational modifications (PTMs) were enriched in the tricarboxylic acid (TCA) cycle, pyruvate metabolism, biosynthesis, and carbon metabolism. In addition, 948 peptides of 437 proteins had overlapping associations with multiple metabolic pathways. Moreover, both acetylation and succinylation were found in many antimicrobial resistance (AMR) proteins, suggesting their potentially vital roles in antibiotic resistance. In general, our work provides insights into the acetylome and succinylome features responsible for the antibiotic resistance mechanism of E. tarda, and the results may facilitate future investigations into the pathogenesis of this bacterium. Full article
(This article belongs to the Special Issue The Molecular Mechanisms of Antibiotic Resistance)
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