The Molecular Mechanisms of Antibiotic Resistance

Dear Colleagues,

Bacterial antibiotic resistance has become a serious public health and environmental problem, beginning with the use of antibiotics over 90 years ago. It is extraordinarily necessary to understand intrinsic antibiotic resistance mechanisms for the development of new antibiotics or strategies in the future. Currently, several typical resistance mechanisms against antibiotics are known, such as reducing cellular membrane permeability or increasing efflux pumps in the bacterial membrane, altering or modifying the structure of attacking proteins, bypassing the inhibited key pathways, and introducing an exogenous plasmid carrying antibiotic resistance genes. However, since intracellular molecular mechanisms are complicated, such as molecular regulation by transcriptional factors, metabolic rearrangement and post-translational modifications (PTMs) in antibiotic resistance, and the diverse adaptation mechanisms within complex changing external environments, there is still a long way to go to reach our goals.

Due to the current poor understanding of bacterial antibiotic resistance, this Special Issue is focused on reports related to the current situation of worldwide bacterial antibiotic resistance mechanisms. We welcome and accept articles exploring antibiotic resistance mechanisms caused by efflux pumps, transferred plasmids, transcriptional factors, antimicrobial resistance genes, PTMs, etc. Furthermore, we also encourage content that provides alternative novel strategies to control or kill antibiotic-resistant bacteria besides the traditional use of antibiotics.

Dr. Bo Peng
Prof. Dr. Xiangmin Lin
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.