Special Issue "Antibiotic Targets in Bacterial DNA Replication and Cell Division"
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (31 August 2020).
Interests: bacterial cell cycle; mechanism and regulation of chromosomal replication initiation; initiator proteins; DNA methylation; antibiotic inhibition of chromosome replication; designing whole cell screens for discovery of new antibiotics; antimicrobial peptides
Special Issues and Collections in MDPI journals
Interests: bacterial DNA replication; protein-protein interactions; protein-DNA interactions; enzymes; antibiotic drug discovery
Interests: bacterial cell division; medicinal honey; natural product antibacterials; mechanisms of action of antibiotics; drug discovery (including natural products, antibiotic resistance)
This issue of Antibiotics is dedicated to the topics of Bacterial DNA Replication and Cell Division and Inhibitors of these processes. DNA replication is a conserved and essential process in all organisms, yet significant differences exist between replication proteins of bacteria and eukaryotic cells. Following replication initiation, for most bacteria governed by the DnaA protein, replication of the bacterial chromosome is carried out by a multi-protein complex called the replisome, which is present in only few copies per cell. The proteins involved in DNA replication should provide an attractive target for antimicrobial inhibition and yet only antibiotics that indirectly target the replication process are in clinical use. These inhibit the type-II topoisomerases that relieve topological stress created by DNA unwinding and decatenate daughter chromosomes prior to cell division.
The process of cell division is also an essential process, elements of which are widely conserved in bacteria. Like DNA replication, bacterial cell division involves a multiprotein assembly, called the divisome, and the process occurs quite differently from division of eukaryotic cells. Discovery of inhibitors of bacterial cell division have focussed on the conserved FtsZ protein that oligomerizes to form contractile rings at the site of division and the enzymes required for peptidoglycan synthesis, but there are many other potential targets.
This Special Issue summarizes current knowledge of bacterial DNA replication and cell division, and their inhibition by antimicrobials. It is our pleasure to invite submissions of high quality primary research manuscripts and review articles addressing the molecular mechanisms of bacterial DNA replication and cell division, their coordination and regulation, and their inhibition by established drugs and novel compounds.
Prof. Dr. Anders Løbner-Olesen
Prof. Dr. Nicholas Dixon
Prof. Dr. Elizabeth Harry
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- bacterial chromosomes
- chromosome and plasmid replication
- bacterial cell division
- replication control
- control of cell division
- replication enzymes
- cell division proteins
- initiation, elongation and termination of replication
- replisome, function and processivity
- divisome, structure and function
- protein-protein interactions
- antibiotic resistance