Novel Antibiotics Targeting Bacterial Replicative DNA Polymerases
Abstract
:1. Introduction
1.1. The Bacterial Replisome
1.2. The Bacterial Replicative DNA Polymerases
2. Inhibiting Bacterial Replicative DNA Polymerases
2.1. Polymerase Active Site Inhibitors
2.2. Allosteric Inhibition
2.3. Exonuclease Inhibitors
2.4. Disrupting Interaction with Replisome Proteins
2.5. Targeting DNA Polymerases to Combat Antibiotic Resistance
3. High-Throughput Screening Methods for Replication Inhibitors
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Compound | Nucleotide | Polymerase | Species | Reference |
---|---|---|---|---|
ACX-362E 1 | Yes | PolC | C. difficile | [41] |
ACX-375C | Yes | PolC | S. aureus, others | Acurxpharma 3 |
Nargenicin | No | DnaE | S. aureus | [40] |
DB04118, DB04698 2 | No | Pol IIIα | E. coli | [42] |
NBH | No | PolC | S. aureus | [43] |
Multiple 2 | Yes, No | DnaE2 4 | M. tuberculosis | [44] |
324C | Yes | DnaE | B. subtilis | [45] |
7-Alkyl-N(2)-substituted-3-deazaguanines | Yes | PolC, Pol IIIα | B. subtilis | [46] |
quinazolin-2-ylamino-quinazolin-4-ols | No | PolC | S. aureus | [47] |
251D | No | PolC | B. subtilis | [48] |
6-Anilinouracil-based | Yes | PolC | B. subtilis | [49] |
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Santos, J.A.; Lamers, M.H. Novel Antibiotics Targeting Bacterial Replicative DNA Polymerases. Antibiotics 2020, 9, 776. https://doi.org/10.3390/antibiotics9110776
Santos JA, Lamers MH. Novel Antibiotics Targeting Bacterial Replicative DNA Polymerases. Antibiotics. 2020; 9(11):776. https://doi.org/10.3390/antibiotics9110776
Chicago/Turabian StyleSantos, Joana A., and Meindert H. Lamers. 2020. "Novel Antibiotics Targeting Bacterial Replicative DNA Polymerases" Antibiotics 9, no. 11: 776. https://doi.org/10.3390/antibiotics9110776