Terpenoids from Microorganisms: Their Chemistry and Biology

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Genetic and Biochemical Studies of Antibiotic Activity and Resistance".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 3809

Special Issue Editor


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Guest Editor
Pharmaceutical Education Center, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan
Interests: natural product chemistry; isolation; structure determination; sterols; terpenoids
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Special Issue Information

Dear Colleagues,

Terpenoids are widespread natural products that are formed from isoprene units, leading to their characteristic structure. Many of them possess biological activities and have been utilized as key lead compounds in drug development. We now plan to edit a Special Issue on “Terpenoids from Microorganisms: Their Chemistry and Biology”. Please submit your recent results of the following areas on terpenoids from microorganisms; isolation, analytical methods, structure determination, synthesis, biosynthesis, enzymatic process, biotranformation, and biological activity. We aim to provide a platform to present the valuable results of your research in these areas.

Assoc. Prof. Dr. Yasunori Yaoita
Guest Editor

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Keywords

  • terpenoids
  • isolation
  • analytical method
  • structure
  • synthesis
  • biosynthesis
  • biotransformation
  • bioactivity

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Published Papers (1 paper)

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Review

29 pages, 5794 KiB  
Review
A Review of Fungal Protoilludane Sesquiterpenoid Natural Products
by Melissa M. Cadelis, Brent R. Copp and Siouxsie Wiles
Antibiotics 2020, 9(12), 928; https://doi.org/10.3390/antibiotics9120928 - 19 Dec 2020
Cited by 10 | Viewed by 3255
Abstract
Natural products have been a great source for drug leads, due to a vast majority possessing unique chemical structures. Such an example is the protoilludane class of natural products which contain an annulated 5/6/4-ring system and are almost exclusively produced by fungi. They [...] Read more.
Natural products have been a great source for drug leads, due to a vast majority possessing unique chemical structures. Such an example is the protoilludane class of natural products which contain an annulated 5/6/4-ring system and are almost exclusively produced by fungi. They have been reported to possess a diverse range of bioactivities, including antimicrobial, antifungal and cytotoxic properties. In this review, we discuss the isolation, structure elucidation and any reported bioactivities of this compound class, including establishment of stereochemistry and any total syntheses of these natural products. A total of 180 protoilludane natural products, isolated in the last 70 years, from fungi, plant and marine sources are covered, highlighting their structural diversity and potential in drug discovery. Full article
(This article belongs to the Special Issue Terpenoids from Microorganisms: Their Chemistry and Biology)
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